Evidence map›Paper›PMID 31022935›Full record

ReviewNanomaterials (Basel, Switzerland)2019

Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy.

Rafael Contreras-Cáceres, Laura Cabeza, Gloria Perazzoli, Amelia Díaz, Juan Manuel López-Romero, Consolación Melguizo, Jose Prados

Open access · goldAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 164 citations in OpenAlex.

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  12. Nedaplatin/Pharmaceutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rafael Contreras-CáceresDepartment of Organic Chemistry, Faculty of Science, University of Málaga, 29071 Málaga, Spain. rafcontr@ucm.es.
Laura CabezaInstitute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. lautea@ugr.es.
Gloria PerazzoliInstitute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. gperazzoli@ugr.es.
Amelia DíazDepartment of Organic Chemistry, Faculty of Science, University of Málaga, 29071 Málaga, Spain. amelia@uma.es.
Juan Manuel López-RomeroDepartment of Organic Chemistry, Faculty of Science, University of Málaga, 29071 Málaga, Spain. jmromero@uma.es.ORCID 0000-0003-2422-655X
Consolación MelguizoInstitute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. melguizo@ugr.es.
Jose PradosInstitute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. jprados@ugr.es.
Universidad de Granada · ESUniversidad de Málaga · ESUniversidad Complutense de Madrid · ES

Funding

TREND THEORY IN COMMUNITY CONTEXTR01DA010736 · NIDA · UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS · PI AGAR, MICHAEL H · 1998 to 2003
$1.0M
CICYT CTQ16-76311Comunidad de Madrid 2018-T1/IND-10736Consejería de Salud de la Junta de Andalucía PI-0102-2017Consejería de Salud de la Junta de Andalucía PI-0476-2016
6 · The paper itself

Abstract

Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (ε-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability.

Indexed as

biocompatible polymerscancer treatmentdrug releaseelectrospun nanofibershyperthermiananomedicine

Identifiers

PMID31022935
PMCPMC6523776
OpenAlexW2942497294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.