Evidence map›Paper›PMID 31022673›Full record

ArticleRedox biology2019

Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing.

Laura C D Pomatto, Patrick Y Sun, Kelsi Yu, Sandhyarani Gullapalli, Conscience P Bwiza, Christina Sisliyan, Sarah Wong, Hongqiao Zhang, Henry Jay Forman, Peter L Oliver and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Nrf2/Bach1 signaling axis: A promising multifaceted therapeutic strategy for Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Insulin and aging - a disappointing relationship.Frontiers in endocrinology · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging.Oxidative medicine and cellular longevity · 2021
    Review
  15. Murine Susceptibility toFrontiers in cellular and infection microbiology · 2021
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Laura C D PomattoLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Patrick Y SunLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Kelsi YuLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Sandhyarani GullapalliLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Conscience P BwizaLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Christina SisliyanLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Sarah WongLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Hongqiao ZhangLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Henry Jay FormanLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
Peter L OliverOxford Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK; MRC Harwell Institute, Harwell Campus, Didcot, Oxfordshire, OX11 0RD, UK.
Kay E DaviesOxford Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Kelvin J A DaviesLeonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA; Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA; Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, University of Southern California, University of Southern California, Los Angeles, CA 90089-0191, USA. Electronic address: kelvin@usc.edu.
University of Southern California · USUniversity of Oxford · GB

Funding

OXYGEN RADICAL TOXICITY AND RED CELL PROTEIN DEGRADATIONR01ES003598 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DAVIES, KELVIN J. A. · 1988 to 2017
$5.7M
USC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3M
Human models of the particulate-induced inflammatory/antioxidant axis in agingR01ES023864 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORMAN, HENRY JAY · 2015 to 2019
$2.4M
Human models of the particulate-induced inflammatory/antioxidant axis in agingR56ES023864 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORMAN, HENRY JAY · 2014 to 2014
$150k
Oxygen Radical Toxicity and Protein DegradationR56ES003598 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DAVIES, KELVIN J. A. · 2012 to 2012
$138k
Medical Research Council MC_EX_MR/P502005/1NIA NIH HHS T32 AG052374NIEHS NIH HHS R01 ES003598NIEHS NIH HHS R01 ES023864NIEHS NIH HHS R56 ES003598NIEHS NIH HHS R56 ES023864
6 · The paper itself

Abstract

The Nrf2 signal transduction pathway plays a major role in adaptive responses to oxidative stress and in maintaining adaptive homeostasis, yet Nrf2 signaling undergoes a significant age-dependent decline that is still poorly understood. We used mouse embryonic fibroblasts (MEFs) cultured under hyperoxic conditions of 40% O

Indexed as

Adaptation, PhysiologicalHomeostasisAgingAnimalsComputational BiologyFibroblastsHydrogen PeroxideHyperoxiaMiceOxidative StressOxygenProteasome Endopeptidase ComplexSignal TransductionHydrogen PeroxideOxygenProteasome Endopeptidase Complex20S proteasomeAdaptive homeostasisBach1c-MycHyperoxiaImmunoproteasomeLon proteaseNQO1Nrf2OXR1

Identifiers

PMID31022673
PMCPMC6479762
OpenAlexW2938027060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.