Evidence map›Paper›PMID 31022672›Full record

ArticleRedox biology2019

Cholesterol crystals promote endothelial cell and monocyte interactions via H

Prahalathan Pichavaram, Arul M Mani, Nikhlesh K Singh, Gadiparthi N Rao

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Atherosclerotic Plaque Crystals Induce Endothelial Dysfunction.International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Prahalathan PichavaramDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Arul M ManiDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Nikhlesh K SinghDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Gadiparthi N RaoDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: rgadipar@uthsc.edu.
University of Tennessee Health Science Center · US

Funding

Non-COX Arachidonic Acid Metabolites and AngiogenesisR01HL074860 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RAO, GADIPARTHI N · 2004 to 2020
$5.9M
NHLBI NIH HHS R01 HL074860
6 · The paper itself

Abstract

In the present study, we show that cholesterol crystals induce NFκB activation, and ICAM1 and VCAM1 expression via xanthine oxidase-mediated H

Indexed as

AnimalsCholesterolDocosahexaenoic AcidsEndothelial CellsHumansHydrogen PeroxideIntercellular Adhesion Molecule-1Leukocytes, MononuclearMiceMonocytesNF-kappa BOxidantsVascular Cell Adhesion Molecule-1CholesterolDocosahexaenoic AcidsHydrogen PeroxideICAM1 protein, humanIntercellular Adhesion Molecule-1NF-kappa BOxidantsresolvin D1Vascular Cell Adhesion Molecule-1Cholesterol crystalsEC-Monocyte interactionsH(2)O(2)ICAM1/VCAM1NFκBPP2AXanthine oxidase

Identifiers

PMID31022672
PMCPMC6477634
OpenAlexW2929981524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.