Evidence map›Paper›PMID 31022661›Full record

ArticleEpilepsy & behavior : E&B2019

High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.

Suzanne O Nolan, Samantha L Hodges, Siena M Condon, Ilyasah D A Muhammed, Lindsay A Tomac, Matthew S Binder, Conner D Reynolds, Joaquin N Lugo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Neonatal immune stimulation results in sex-specific changes in ultrasonic vocalizations but does not affect seizure susceptibility in neonatal mice.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2024
    Article
  3. Article
  4. Article
  5. Novel Therapeutics for Neonatal Seizures.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suzanne O NolanDepartment of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA.
Samantha L HodgesInstitute of Biomedical Studies, Baylor University, Waco, TX 76798, USA.
Siena M CondonUniversity Scholars Program, Baylor University, Waco, TX 76798, USA.
Ilyasah D A MuhammedDepartment of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA.
Lindsay A TomacDepartment of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA.
Matthew S BinderDepartment of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA.
Conner D ReynoldsTexas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Joaquin N LugoDepartment of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA; Institute of Biomedical Studies, Baylor University, Waco, TX 76798, USA; Department of Biology, Baylor University, Waco, TX 76798, USA. Electronic address: joaquin_lugo@baylor.edu.

Funding

Signaling Mechanisms Underlying Epilepsy and Autism CormorbidityR15NS088776 · NINDS · BAYLOR UNIVERSITY · PI JOAQUIN N LUGO · 2015 to 2026
$1.8M
NINDS NIH HHS R15 NS088776
6 · The paper itself

Abstract

There is increasing evidence that seizures during early development can impact ultrasonic vocalizations (USVs) emitted from neonatal mice. However, most of the effects of early-life seizures have been reported using chemoconvulsants that produce continuous seizures (status epilepticus). In the present study, we evaluated the impact of different seizure frequency loads during early-life vocalization development in C57BL/6J male and female mice. For the high seizure load (HSL) paradigm, we administered 3 flurothyl seizures to mice on postnatal day (PD) 7 through PD11, and recorded USVs on PD12. We found that the induction of seizures across PD7-11 resulted in increased average duration (P < 0.05) and cumulative duration (P < 0.05) of USVs across both sexes. Call-type analyses indicated several call-type changes, including reduced production of complex call-types from males' HSL condition. For the low seizure load (LSL) paradigm, we induced 3 flurothyl seizures only on PD10 and recorded USVs on PD12. We found no change in any spectral or temporal features of USVs. However, call-type production analyses indicated that both male and female animals from the LSL paradigm also produced changes in call-types. This study provides evidence that the magnitude of communication impairment following seizures is significantly impacted by seizure frequency load early in development.

Indexed as

Growth and DevelopmentUltrasonic WavesVocalization, AnimalAnimalsAnimals, NewbornFemaleMaleMiceMice, Inbred C57BLRandom AllocationSeizuresSeverity of Illness IndexAutismCritical periodDevelopmental disorderFlurothylSpectrogram

Identifiers

PMID31022661
PMCPMC6546518

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.