ArticleJournal of psychiatric research2019
Analyzing DNA methylation patterns in subjects diagnosed with schizophrenia using machine learning methods.
Article in Journal of psychiatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders - a systematic review.Neurogenetics · 2024Pooled it
- Exploring the Intersection of Schizophrenia, Machine Learning, and Genomics: Scoping Review.JMIR bioinformatics and biotechnology · 2024Article
- DiseaseNet: a transfer learning approach to noncommunicable disease classification.BMC bioinformatics · 2024Article
- Global DNA and RNA Methylation Signature in Response to Antipsychotic Treatment in First-Episode Schizophrenia Patients.Neuropsychiatric disease and treatment · 2024Article
- A machine learning case-control classifier for schizophrenia based on DNA methylation in blood.Translational psychiatry · 2021Article
- DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy.BMC genomics · 2021Article
- Exploring autoantibody signatures in brain tissue from patients with severe mental illness.Translational psychiatry · 2020Article
- Genome-Wide Identification and Analysis of the Methylation of lncRNAs and Prognostic Implications in the Glioma.Frontiers in oncology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
Schizophrenia is a common mental disorder with high heritability. It is genetically complex and to date more than a hundred risk loci have been identified. Association of environmental factors and schizophrenia has also been reported, while epigenetic analyses have yielded ambiguous and sometimes conflicting results. Here, we analyzed fresh frozen post-mortem brain tissue from a cohort of 73 subjects diagnosed with schizophrenia and 52 control samples, using the Illumina Infinium HumanMethylation450 Bead Chip, to investigate genome-wide DNA methylation patterns in the two groups. Analysis of differential methylation was performed with the Bioconductor Minfi package and modern machine-learning and visualization techniques, which were shown previously to be successful in detecting and highlighting differentially methylated patterns in case-control studies. In this dataset, however, these methods did not uncover any significant signals discerning the patient group and healthy controls, suggesting that if there are methylation changes associated with schizophrenia, they are heterogeneous and complex with small effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.