ReviewBiomaterials2019
The cell in the ink: Improving biofabrication by printing stem cells for skeletal regenerative medicine.
Review in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric and visualized analysis of 3D printing bioink in bone tissue engineering.Frontiers in bioengineering and biotechnology · 2023Pooled it
- Advancing Stem Cell Bioprinting to Bridge Engineered and Natural Tissue Constructs.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- 3D bioprinting of cell-laden constructs: technologies, bioink design, and biomedical applications.Biomedical materials (Bristol, England) · 2025Review
- Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers.Annals of medicine · 2025Review
- An Overview of 3D Bioprinting Impact on Cell Viability: From Damage Assessment to Protection Solutions.Journal of functional biomaterials · 2025Review
- Innovative applications of 3D printing in personalized medicine and complex drug delivery systems.iScience · 2025Review
- From Medical Imaging to Bioprinted Tissues: The Importance of Workflow Optimisation for Improved Cell Function.Expert reviews in molecular medicine · 2025Review
- Microgel-based bioink for extrusion-based 3D bioprinting and its applications in tissue engineering.Bioactive materials · 2025Review
- Review
- Recapitulating the bone extracellular matrix through 3D bioprinting using various crosslinking chemistries.Frontiers in bioengineering and biotechnology · 2025Review
- Article
- Engineered nascent living human tissues with unit programmability.Nature materials · 2025Article
- Modeling intratumor heterogeneity in breast cancer.Biofabrication · 2024Review
- Computational methods for biofabrication in tissue engineering and regenerative medicine - a literature review.Computational and structural biotechnology journal · 2024Review
- Article
- Effect of viscosity of gelatin methacryloyl-based bioinks on bone cells.Biofabrication · 2024Article
- 3D Bioprinting of Microbial-based Living Materials for Advanced Energy and Environmental Applications.Chem & bio engineering · 2024Review
- Optimising Bioprinting Nozzles through Computational Modelling and Design of Experiments.Biomimetics (Basel, Switzerland) · 2024Review
- Single/Multi-Network Conductive Hydrogels-A Review.Polymers · 2024Review
- Evaluation of Alginate Hydrogel Microstrands for Stromal Cell Encapsulation and Maintenance.Bioengineering (Basel, Switzerland) · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Recent advances in regenerative medicine have confirmed the potential to manufacture viable and effective tissue engineering 3D constructs comprising living cells for tissue repair and augmentation. Cell printing has shown promising potential in cell patterning in a number of studies enabling stem cells to be precisely deposited as a blueprint for tissue regeneration guidance. Such manufacturing techniques, however, face a number of challenges including; (i) post-printing cell damage, (ii) proliferation impairment and, (iii) poor or excessive final cell density deposition. The use of hydrogels offers one approach to address these issues given the ability to tune these biomaterials and subsequent application as vectors capable of delivering cell populations and as extrusion pastes. While stem cell-laden hydrogel 3D constructs have been widely established in vitro, clinical relevance, evidenced by in vivo long-term efficacy and clinical application, remains to be demonstrated. This review explores the central features of cell printing, cell-hydrogel properties and cell-biomaterial interactions together with the current advances and challenges in stem cell printing. A key focus is the translational hurdles to clinical application and how in vivo research can reshape and inform cell printing applications for an ageing population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.