ArticlePloS one2019
Canine infectious respiratory disease: New insights into the etiology and epidemiology of associated pathogens.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- A Novel Vitamin E Adjuvanted InjectableVaccines · 2026Article
- Clinical features, risk factors, and outcomes of Bordetella bronchiseptica respiratory infections in dogs diagnosed at a tertiary care institution.Journal of veterinary internal medicine · 2026Article
- A targeted PCR approach for the detection of IOLA in canine infectious respiratory disease samples during an atypical CIRD outbreak in winter 2023.Frontiers in veterinary science · 2026Article
- Development and validation of nanoplate-based RT-dPCR assay for canine respiratory coronavirus detection in various clinical samples.BMC veterinary research · 2025Article
- Development of Multiplex PCR assay for detection of Canine Infectious Respiratory Disease Complex (CIRDC) pathogens in dogs.Frontiers in cellular and infection microbiology · 2025Article
- Automated highly multiplex detection system for respiratory pathogens in canines.Frontiers in veterinary science · 2025Article
- Molecular detection of canine viral infectious diseases in China: an investigation from 2018 to 2024.Frontiers in veterinary science · 2025Article
- Development of one-step multiplex real-time PCR for the detection of CHV-1, CAdV-2, and CDV.Frontiers in veterinary science · 2025Article
- Detection of pathogens in dogs with respiratory disease during winter 2023-2024 using multiplex qPCR/RT-qPCR assays and next-generation sequencing.Frontiers in veterinary science · 2025Article
- Risk factors for canine infectious respiratory disease complex and the pathogens associated with the disease.The Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
- Feline respiratory disease complex: insights into the role of viral and bacterial co-infections.Frontiers in microbiology · 2024Article
- Epidemiologic investigation and genetic characterization of canine respiratory coronavirus in the Southeastern United States.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Article
- Predominance of Canine Parainfluenza Virus andPathogens (Basel, Switzerland) · 2023Article
- Review
- Article
- Mucosal Vaccination with Live AttenuatedVaccines · 2023Article
- Canine Parainfluenza Virus Infection in a Dog with Acute Respiratory Disease.Veterinary sciences · 2022Article
- The impact of the COVID-19 pandemic on a cohort of Labrador retrievers in England.BMC veterinary research · 2022Article
- Clinical and molecular aspects of veterinary coronaviruses.Virus research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Canine infectious respiratory disease (CIRD) is a syndrome where multiple viral and bacterial pathogens are involved sequentially or synergistically to cause illness. There is limited information regarding the prevalence of pathogens related to CIRD in the United States as well as the role of co-infections in the pathogenesis of the syndrome. We aimed to conduct a comprehensive etiologic and epidemiologic study of multiple CIRD agents in a diverse dog population using molecular methods and statistical modeling analyses. In addition, a novel probe-based multiplex real-time PCR was developed to simultaneously detect and differentiate two species of Mycoplasma (M. canis and M. cynos). Canine adenovirus, canine distemper virus, canine parainfluenza virus, coronavirus, influenza A virus (H3N2 and H3N8), Bordetella bronchiseptica, M. canis, M. cynos and Streptococcus equi subsp. zooepidemicus were investigated in specimens from clinically ill and asymptomatic dogs received at the Athens Veterinary Diagnostic Laboratory. Results showed low occurrence of classical CIRD agents such as B. bronchiseptica, canine adenovirus and distemper virus, while highlighting the potential role of emerging bacteria such as M. canis and M. cynos. Statistical modeling analyses of CIRD pathogens emphasized the impact of co-infections on the severity of clinical presentation, and showed that host factors, such as animal age, are the most important predictors of disease severity. This study provides new insights into the current understanding of the prevalence and role of co-infections with selected viruses and bacteria in the etiology of CIRD, while underscoring the importance of molecular diagnosis and vaccination against this disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.