Evidence map›Paper›PMID 31021723›Full record

ArticleCirculation research2019

Acetylation of SERCA2a, Another Target for Heart Failure Treatment?

Xiongwen Chen, Xiaoying Zhang, Scott Gross, Steven R Houser, Jonathan Soboloff

Abstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Mechanisms underlying pathological CaPflugers Archiv : European journal of physiology · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. SERCA2a: a key protein in the CaHeart failure reviews · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xiongwen ChenFrom the Cardiovascular Research Center (X.C., X.Z., S.R.H.), Temple University School of Medicine, Philadelphia, PA.
Xiaoying ZhangFrom the Cardiovascular Research Center (X.C., X.Z., S.R.H.), Temple University School of Medicine, Philadelphia, PA.
Scott Grossthe Fels Institute for Cancer Research and Molecular Biology (S.G., J.S.), Temple University School of Medicine, Philadelphia, PA.
Steven R HouserFrom the Cardiovascular Research Center (X.C., X.Z., S.R.H.), Temple University School of Medicine, Philadelphia, PA.
Jonathan Soboloffthe Fels Institute for Cancer Research and Molecular Biology (S.G., J.S.), Temple University School of Medicine, Philadelphia, PA.

Funding

Targeted Cancer Therapeutics and Heart Failure: Mechanisms and Post-injury RepairP01HL091799 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI HOUSER, STEVEN R · 2008 to 2018
$23.1M
Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Raj Kishore · 2017 to 2026
$21.0M
Calcium and Cardiac Regeneration after Myocardial InfarctionR01HL033921 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 1985 to 2017
$5.6M
Protein Kinase A Inhibitor Peptide (PKI) and Cardiac Protection in Heart FailureR01HL088243 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEN, XIONGWEN · 2007 to 2017
$4.0M
Paracrine hypothesis underlying cardiac stem cell therapyR01HL132391 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R, MOLKENTIN, JEFFERY D · 2016 to 2019
$3.1M
Cortical Bone Stem Cell Therapy for the Infarcted HeartR01HL139960 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 2018 to 2021
$2.5M
Compartmental PKA and Pathological Cardiac HypertrophyR01HL140071 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 2018 to 2021
$1.6M
EGR-mediated STIM1-PMCA expression and function in T cell subsetsR01GM117907 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI SOBOLOFF, JONATHAN A · 2016 to 2019
$1.6M
TRPC Channel Regulation of Cardiac Hypertrophy and ContractilityR01HL119229 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 2014 to 2017
$1.1M
Synthetic rescue of antigen-driven T cells and alloimmunityR56AI143256 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI SOBOLOFF, JONATHAN A, ZHANG, YI · 2019 to 2019
$353k
NHLBI NIH HHS P01 HL091799NHLBI NIH HHS P01 HL134608NHLBI NIH HHS R01 HL033921NHLBI NIH HHS R01 HL088243NHLBI NIH HHS R01 HL119229NHLBI NIH HHS R01 HL132391NHLBI NIH HHS R01 HL139960NHLBI NIH HHS R01 HL140071NIAID NIH HHS R56 AI143256NIGMS NIH HHS R01 GM117907
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Heart FailureSarcoplasmic Reticulum Calcium-Transporting ATPasesAcetylationHumansSarcoplasmic ReticulumSirtuin 1Sarcoplasmic Reticulum Calcium-Transporting ATPasesSIRT1 protein, humanSirtuin 1acetylationaction potentialEditorialsheart failuresarcoplasmic reticulum

Identifiers

PMID31021723
PMCPMC6564686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.