Evidence map›Paper›PMID 31021676›Full record

ArticleJournal of speech, language, and hearing research : JSLHR2019

Reference Values for Healthy Swallowing Across the Range From Thin to Extremely Thick Liquids.

Catriona M Steele, Melanie Peladeau-Pigeon, Carly A E Barbon, Brittany T Guida, Ashwini M Namasivayam-MacDonald, Weslania V Nascimento, Sana Smaoui, Melanie S Tapson, Teresa J Valenzano, Ashley A Waito and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of speech, language, and hearing research : JSLHR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04537650 (The Pathophysiology of Swallowing Impairment in People Recovering From COVID-19), which is not on this map. Cited by 107 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04537650 completednot on this mapstarted 2021, after this paper: background citation

The Pathophysiology of Swallowing Impairment in People Recovering From COVID-19

TypeobservationalSponsorUniversity Health Network, TorontoRan2021 to 2022Enrolled44ConditionsCovid19ArmsVideofluoroscopic Swallowing Study (VFSS)
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Effects of Puree Type and Color on Ratings of Pharyngeal Residue, Penetration, and Aspiration during FEES: A Prospective Study of 37 Dysphagic Outpatient Adults.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2025
    Trial
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Accuracy of Visual Inspection of Thickened Liquids: Implications for Multidisciplinary Dysphagia Management and Clinical Nutrition.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  12. Demographic Factors in Pharyngoesophageal Segment Size: A Scoping Review.Laryngoscope investigative otolaryngology · 2026
    Review
  13. Observational
  14. Thin Liquid Sip Sizes in Outpatient Adults with Normal and Disordered Swallowing: Modifying Factors and Relationships with Swallowing Safety and Efficiency.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Catriona M SteeleSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Melanie Peladeau-PigeonSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Carly A E BarbonSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Brittany T GuidaSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Ashwini M Namasivayam-MacDonaldSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Weslania V NascimentoSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Sana SmaouiSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Melanie S TapsonSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Teresa J ValenzanoSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Ashley A WaitoSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.
Talia S WolkinSwallowing Rehabilitation Research Laboratory, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada.

Funding

Establishing Reference Values and Clinical Decision Points for Quantitative Videofluoroscopic Measures of SwallowingR01AG077481 · NIA · UNIVERSITY HEALTH NETWORK · PI Emily Kate Plowman, Catriona Margaret Steele · 2022 to 2026
$4.3M
Tongue-pressure timing for liquid flow detection and control in swallowingR01DC011020 · NIDCD · UNIVERSITY HEALTH NETWORK · PI STEELE, CATRIONA MARGARET · 2010 to 2020
$2.9M
NIA NIH HHS R01 AG077481NIDCD NIH HHS R01 DC011020
6 · The paper itself

Abstract

Purpose Thickened liquids are frequently used as an intervention for dysphagia, but gaps persist in our understanding of variations in swallowing behavior based on incremental thickening of liquids. The goal of this study was to establish reference values for measures of bolus flow and swallowing physiology in healthy adults across the continuum from thin to extremely thick liquids. Method A sex-balanced sample of 38 healthy adults underwent videofluoroscopy and swallowed 20% weight-to-volume concentration barium prepared in thin and slightly, mildly, moderately, and extremely thick consistencies using a xanthan gum thickener. Participants took comfortable sips and swallowed without a cue; sip volume was measured based on presip and postsip cup weights. A standard operating procedure (the ASPEKT method: Analysis of Swallowing Physiology: Events, Kinematics and Timing) was used to analyze videofluoroscopy recordings. Results The results clarify that, for thin liquid sips (10-14 ml), a single swallow without clearing swallows is typical and is characterized by complete laryngeal vestibule closure, complete pharyngeal constriction, and minimal postswallow residue. Aspiration was not seen, and penetration was extremely rare. Bolus position at swallow onset was variable, extending as low as the pyriform sinuses in 37% of cases. With thicker liquids, no changes in event sequencing, laryngeal vestibule closure, pharyngeal constriction, or postswallow residue were seen. The odds of penetration were significantly reduced. A longer timing interval until onset of the hyoid burst movement was seen, with an associated higher bolus position at swallow onset. Other timing measures remained unaffected by changes in bolus consistency. Conclusion The results include new reference data for swallowing in healthy adults across the range from thin to extremely thick liquids.

Indexed as

AdultBarium SulfateContrast MediaDeglutitionFemaleFood AdditivesHumansMaleMiddle AgedPolysaccharides, BacterialReference ValuesYoung AdultBarium SulfateContrast MediaFood AdditivesPolysaccharides, Bacterialxanthan gum

Identifiers

PMID31021676
PMCPMC6808317

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.