ArticleACS synthetic biology2019
Synthetic Bistability and Differentiation in Yeast.
Article in ACS synthetic biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multistability and predominant hybrid phenotypes in a four node mutually repressive network of Th1/Th2/Th17/Treg differentiation.NPJ systems biology and applications · 2024Article
- Cell-type memory in a single-cell eukaryote requires the continuous presence of a specific transcription regulator.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Synthetic biology for the engineering of complex wine yeast communities.Nature food · 2022Review
- Article
- A light tunable differentiation system for the creation and control of consortia in yeast.Nature communications · 2021Article
- Decoding and recoding plant development.Plant physiology · 2021Review
- A genome-scale yeast library with inducible expression of individual genes.Molecular systems biology · 2021Article
- Genetic circuit design automation for yeast.Nature microbiology · 2020Article
- Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch.Molecular systems biology · 2020Article
- Organizing genome engineering for the gigabase scale.Nature communications · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Engineered systems that control cellular differentiation and pattern formation are essential for applications like tissue engineering, biomaterial fabrication, and synthetic ecosystems. Synthetic circuits that can take on multiple states have been made to engineer multicellular systems. However, how to use these states to drive interesting cellular behavior remains challenging. Here, we present a cellular differentiation program involving a novel synthetic bistable switch coupled to an antibiotic resistance gene that affects growth in yeast ( S. cerevisiae). The switch is composed of a positive feedback loop involving a novel transcription factor and can be switched ON and OFF via two different transient inducer inputs. By further coupling the bistable switch with an antibiotic resistance gene, we obtained a growth differentiation circuit, where yeast cells can be switched to stable HIGH or LOW growth rate states via transient inducer inputs. This work demonstrates a rationally designed and experimentally validated cellular differentiation behavior in yeast.
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Registered trials
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