Evidence map›Paper›PMID 31021461›Full record

ArticleStem cells (Dayton, Ohio)2019

Activation-Induced Cytidine Deaminase Regulates Fibroblast Growth Factor/Extracellular Signal-Regulated Kinases Signaling to Achieve the Naïve Pluripotent State During Reprogramming.

Ritu Kumar, Todd Evans

Open access · hybridAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ritu KumarDepartment of Surgery, Weill Cornell Medicine, New York, New York, USA.
Todd EvansDepartment of Surgery, Weill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-7148-9849
Cornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induced pluripotent stem cells (iPSCs) derived by in vitro reprogramming of somatic cells retain the capacity to self-renew and to differentiate into many cell types. Pluripotency encompasses multiple states, with naïve iPSCs considered as ground state, possessing high levels of self-renewal capacity and maximum potential without lineage restriction. We showed previously that activation-induced cytidine deaminase (AICDA) facilitates stabilization of pluripotency during reprogramming. Here, we report that Acida

Indexed as

Cellular ReprogrammingMAP Kinase Signaling SystemAICDA (Activation-Induced Cytidine Deaminase)AnimalsCell LineCellular Reprogramming TechniquesCytidine DeaminaseExtracellular Signal-Regulated MAP KinasesFibroblast Growth FactorsInduced Pluripotent Stem CellsMiceAICDA (Activation-Induced Cytidine Deaminase)Cytidine DeaminaseExtracellular Signal-Regulated MAP KinasesFibroblast Growth FactorsDNA methylationEpigeneticsiPSCsMitogen-activated protein kinase signaling

Identifiers

PMID31021461
PMCPMC6766926
OpenAlexW2941775546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.