ArticleHistopathology2019
Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early-stage oral squamous cell carcinoma.
Article in Histopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Has the 8th American joint committee on cancer TNM staging improved prognostic performance in oral cancer? A systematic review.Medicina oral, patologia oral y cirugia bucal · 2024Pooled it
- Emerging histopathologic markers in early-stage oral tongue cancer: A systematic review and meta-analysis.Head & neck · 2022Pooled it
- Histopathological Definitions of Extranodal Extension: A Systematic Review.Head and neck pathology · 2021Pooled it
- History of Oral Mucosal Lesions in Oral Squamous Cell Carcinoma Patients.Oral health & preventive dentistry · 2025Article
- Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis.The Japanese dental science review · 2024Review
- Do we recognize oral cancer? Primary professional delay in diagnosis of oral squamous cell carcinoma.Clinical oral investigations · 2024Article
- A preoperative nomogram model for the prediction of lymph node metastasis in buccal mucosa cancer.Cancer medicine · 2023Article
- Rapid multi-task diagnosis of oral cancer leveraging fiber-optic Raman spectroscopy and deep learning algorithms.Frontiers in oncology · 2023Article
- Anti-Tumoral Effects of a (1Pharmaceuticals (Basel, Switzerland) · 2021Article
- Preoperative C-reactive protein to albumin ratio and oral health in oral squamous cell carcinoma patients.BMC oral health · 2021Article
- Comparison of Different Staging Systems Applied to a Cohort of Patients With Oral Tongue and Floor of the Mouth Cancer.Frontiers in oral health · 2021Article
- Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience.Cancers · 2020Article
- Treatment of facial myiasis in an elderly patient with oral squamous cell carcinoma: Case report.International journal of surgery case reports · 2020Article
- Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early-stage oral squamous cell carcinoma.Histopathology · 2019Article
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8 authors.
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Abstract
aimsIn the 8th edition of the American Joint Committee on Cancer TNM staging manual, tumour infiltration depth and extranodal extension are added to the pathological classification for oral squamous cell carcinoma. The currently available 8th TNM validation studies lack patients with conservative neck treatment, and changes in the classification especially affect patients with small tumours. The aim of this study was to determine the potential impact of the changes in the 8th edition pTNM classification on the prognosis and treatment strategy for oral squamous cell carcinoma in a well-defined series of pT1-T2 patients with long-term follow-up. METHODS AND
resultsTwo hundred and eleven first primary pT1-T2 oral squamous cell carcinoma patients, with surgical resection as primary treatment, were analysed retrospectively. One hundred and seventy-three patients underwent a neck dissection, and 38 patients had frequent clinical neck assessments. Long-term follow-up (median 64 months) and reassessed tumour infiltration depth were available. Classification according to the 8th edition criteria resulted in 36% total upstaging with the T classification and 16% total upstaging with the N classification. T3-restaged patients (n = 30, 14%) had lower 5-year disease-specific survival rates than T2-staged patients (81% versus 67%, P = 0.042). Postoperative (chemo)radiotherapy could have been considered in another seven (3%) patients on the basis of the 8th edition criteria.
conclusionsAddition of tumour infiltration depth and extranodal extension in the 8th TNM classification leads to the identification of oral squamous cell carcinoma patients with a worse prognosis who might benefit from an improved postoperative treatment strategy.
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