ArticleJournal of the American Heart Association2019
Cord Blood Vitamin D Levels and Early Childhood Blood Pressure: The Healthy Start Study.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 15 citations in OpenAlex.
- The association of newborn metabolites with early-life wheezing and asthma among US children in the ECHO Program.Communications medicine · 2026Article
- Associations of umbilical cord vitamin D levels with childhood cardiometabolic risks: a longitudinal mother-child study.Frontiers in nutrition · 2026Article
- Role of Maternal Vitamin DJournal of the American Heart Association · 2025Article
- Association between vitamin D status and cardiometabolic risk factors in adults with type 2 diabetes in Shenzhen, China.Frontiers in endocrinology · 2024Article
- Heart Rate and Heart Rate Variability in Healthy Preterm-Born Young Adults and Association with Vitamin D: A Wearable Device Assessment.Journal of clinical medicine · 2023Article
- The Associations of Maternal Health Characteristics, Newborn Metabolite Concentrations, and Child Body Mass Index among US Children in the ECHO Program.Metabolites · 2023Article
- Early pregnancy vitamin D status is associated with blood pressure in children: an Odense Child Cohort study.The American journal of clinical nutrition · 2022Observational
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- Article
- Epigenome-wide association study of maternal hemoglobin A1c in pregnancy and cord blood DNA methylation.Epigenomics · 2021Article
- Determinants of vitamin D status in Kenyan calves.Scientific reports · 2020Article
- Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort.International journal of obesity (2005) · 2020Observational
- Associations of Cord Blood Vitamin D and Preeclampsia With Offspring Blood Pressure in Childhood and Adolescence.JAMA network open · 2020Article
- Vitamin D and Cardiovascular Risk: which Implications in Children?International journal of molecular sciences · 2020Review
- Cord Blood Vitamin D Levels and Early Childhood Blood Pressure: The Healthy Start Study.Journal of the American Heart Association · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Background Vitamin D deficiency is associated with cardiovascular events among adults, but it is unclear whether early-life vitamin D deficiency influences cardiovascular risk factors in children. Methods and Results We measured total and bioavailable 25-dihydroxyvitamin D (25OHD) in cord blood and in blood from 4- to 6-year-old children, and we assessed cardiovascular risk factors (blood pressure, arterial stiffness, body size, and adiposity) at 4 to 6 years. We tested for racial/ethnic differences in total and bioavailable 25OHD (n=715) and modeled the adjusted association between cord blood 25OHD and childhood cardiovascular risk factors (n=171). We observed racial/ethnic differences in total and bioavailable 25OHD levels in both cord and child blood samples (all P<0.05). Each 25-nmol/L increase in cord blood total 25OHD was associated with a 2.5-mm Hg (SE 0.8) decrease in systolic blood pressure ( P=0.002) and a 1.7-mm Hg (SE 0.6) decrease in diastolic blood pressure ( P=0.01), independent of childhood 25OHD levels, race/ethnicity, and other covariates. There was no association between cord blood total 25OHD and any other cardiovascular risk factors. Cord blood levels of bioavailable and free 25OHD were not associated with any cardiovascular risk factor in childhood. Conclusions In this diverse prebirth cohort, we observed lower systolic and diastolic blood pressure among children with higher total 25OHD levels at birth. Our findings suggest that intrauterine exposure to vitamin D may contribute to early-life programming of offspring blood pressure. Intervention studies are needed to determine whether increasing fetal vitamin D exposure can reduce the risk of elevated blood pressure in childhood.
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