Evidence map›Paper›PMID 31020889›Full record

ArticleThe Journal of international medical research2019

Ovarian preservation for premenopausal women with early-stage endometrial cancer: a Chinese retrospective study.

Tianjiao Lyu, Lu Guo, Xiaojun Chen, Nan Jia, Chao Gu, Menghan Zhu, Yuqing Zhao, Xiaoxia Liu, Weiwei Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.Virchows Archiv : an international journal of pathology · 2021
    Guideline
  2. Autophagy-related long non-coding RNA signature for ovarian cancer.The Journal of international medical research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tianjiao Lyu1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Lu Guo1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Xiaojun Chen1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Nan Jia1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Chao Gu1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Menghan Zhu1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Yuqing Zhao1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Xiaoxia Liu1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Weiwei Feng1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Obstetrics and Gynecology Hospital of Fudan University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to retrospectively investigate the safety of ovarian preservation of premenopausal women with stage 1a endometrial carcinoma.

methodsWe performed a population-based study to identify surgically treated stage Ia endometrial cancer of premenopausal women who were diagnosed between August 1989 and December 2015 in our center. Survival outcomes and recurrence rate were examined for premenopausal women who underwent ovarian preservation. Recurrence-free survival rates were calculated following generation of Kaplan-Meier curves and were compared with the log-rank test. Cox regression analysis was performed to identify the independent factors affecting the recurrence rate.

resultsPatients with ovarian preservation tended to be significantly younger at diagnosis, have less myometrial invasion, and were less likely to undergo lymphadenectomy compared with women treated with bilateral salpingo-oophorectomy. There was no significant difference in recurrence-free survival between the two groups. In the Cox regression model, ovarian preservation remained an independent prognostic factor for improved overall survival.

conclusionOvarian preservation does not have a negative effect on oncological outcomes. Ovarian preservation can be applied to premenopausal women with stage Ia endometrial carcinoma.

Indexed as

PremenopauseAdultCase-Control StudiesEndometrial NeoplasmsFemaleFertility PreservationFollow-Up StudiesHumansHysterectomyLymph Node ExcisionMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingOrgan Sparing TreatmentsOvariectomyOvarybilateral salpingo-oophorectomyendometrial cancerlymphadenectomyOvarian preservationpremenopausal womenrecurrence-free survival

Identifiers

PMID31020889
PMCPMC6567715
OpenAlexW2941530418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.