Evidence map›Paper›PMID 31020786›Full record

ReviewStem cells translational medicine2019

Concise Review: Precision Matchmaking: Induced Pluripotent Stem Cells Meet Cardio-Oncology.

Pooja Nair, Maricela Prado, Isaac Perea-Gil, Ioannis Karakikes

Abstract readReview
In one paragraph

Review in Stem cells translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pooja NairDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
Maricela PradoDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
Isaac Perea-GilDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
Ioannis KarakikesDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-4348-600X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As common chemotherapeutic agents are associated with an increased risk of acute and chronic cardiovascular complications, a new clinical discipline, cardio-oncology, has recently emerged. At the same time, the development of preclinical human stem cell-derived cardiovascular models holds promise as a more faithful platform to predict the cardiovascular toxicity of common cancer therapies and advance our understanding of the underlying mechanisms contributing to the cardiotoxicity. In this article, we review the recent advances in preclinical cancer-related cardiotoxicity testing, focusing on new technologies, such as human induced pluripotent stem cell-derived cardiomyocytes and tissue engineering. We further discuss some of the limitations of these technologies and present future directions. Stem Cells Translational Medicine 2019;8:758&767.

Indexed as

AnimalsAntineoplastic AgentsCardiotoxicityDrug Evaluation, PreclinicalHumansInduced Pluripotent Stem CellsLab-On-A-Chip DevicesMyocytes, CardiacOrganoidsPrecision MedicinePrimary Cell CultureAntineoplastic AgentsCancerCardiacChemotherapyInduced pluripotent stem cellsToxicity

Identifiers

PMID31020786
PMCPMC6646696

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.