Evidence map›Paper›PMID 31020713›Full record

ArticleMagnetic resonance in medicine2019

Development of a fast-scan EPR imaging system for highly accelerated free radical imaging.

Alexandre Samouilov, Rizwan Ahmad, James Boslett, Xiaoping Liu, Sergey Petryakov, Jay L Zweier

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Rapid scan EPR: Automated digital resonator control for low-latency data acquisition.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022
    Article
  3. Article
  4. Article
  5. High fidelity triangular sweep of the magnetic field for millisecond scan EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021
    Article
  6. Article
  7. ArrhythmoGenoPharmacoTherapy.Frontiers in pharmacology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexandre SamouilovDavis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio.
Rizwan AhmadDavis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio.
James BoslettDavis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio.
Xiaoping LiuDavis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio.
Sergey PetryakovGeisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
Jay L ZweierDavis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio.
The Ohio State University · USDartmouth College · US

Funding

Role of Cytoglobin in the Regulation of Vascular ToneR01HL131941 · NHLBI · OHIO STATE UNIVERSITY · PI JAY Louis ZWEIER · 2017 to 2026
$5.7M
In vivo monitoring of tumor microenvironment regulation for macrophagesR01CA194013 · NCI · WEST VIRGINIA UNIVERSITY · PI Timothy D Eubank, Valery V Khramtsov · 2015 to 2026
$3.5M
Proton Electron Double Resonance Imaging (PEDRI) of Free RadicalsR01EB004900 · NIBIB · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2005 to 2008
$3.4M
In Vivo EPR/NMR Co-Imaging of Free RadicalsR01EB000890 · NIBIB · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2002 to 2005
$2.9M
Mechanisms of Nicotine Inhalation-Induced Cardiovascular DiseaseR01HL135648 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2017 to 2021
$2.6M
Integration of High Field MRI and EPRI For Functional ImagingR01EB016096 · NIBIB · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2013 to 2016
$2.3M
Functional proton-electron double-resonance imaging: development and applicationR01EB014542 · NIBIB · OHIO STATE UNIVERSITY · PI KHRAMTSOV, VALERY V, SAMOUILOV, ALEXANDRE VALENTIN · 2012 to 2015
$1.3M
NCI NIH HHS R01 CA194013NHLBI NIH HHS R01 HL131941NHLBI NIH HHS R01 HL135648NIBIB NIH HHS R01 EB000890NIBIB NIH HHS R01 EB004900NIBIB NIH HHS R01 EB014542NIBIB NIH HHS R01 EB016096
6 · The paper itself

Abstract

purposeIn continuous wave EPR imaging, the acquisition of high-quality images was previously limited by the requisite long acquisition times of each image projection that was typically greater than 1 second. To accelerate the process of image acquisition facilitating greater numbers of projections and higher image resolution, instrumentation was developed to greatly accelerate the magnetic field scan that is used to obtain each EPR image projection.

methodsA low-inductance solenoidal coil for field scanning was used along with a spherical solenoid air core magnet, and scans were driven by triangular symmetric waves, allowing forward and reverse spectrum acquisition as rapid as 3.8 ms. The uniform distribution of projections was used to optimize the contribution of projections for 3D image reconstruction.

resultsUsing this fast-scan EPR system, high-quality EPR images of phantoms and perfused rat hearts were performed using trityl or nanoparticulate LiNcBuO (lithium octa-n-butoxy-substituted naphthalocyanine) probes with fast-scan EPR imaging at L-band, achieving spatial resolutions of up to 250 micrometers in 1 minute.

conclusionFast-scan EPR imaging can greatly facilitate the efficient and precise mapping of the spatial distribution of free radical and other paramagnetic probes in living systems.

Indexed as

AnimalsElectron Spin Resonance SpectroscopyFree RadicalsHeartImaging, Three-DimensionalMagnetic Resonance ImagingPhantoms, ImagingRatsFree Radicalscontinuous waveelectron paramagnetic resonance imagingfast-scan acquisitioninstrument development

Identifiers

PMID31020713
PMCPMC6510602
OpenAlexW2941750893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.