ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2019
Characterization and Imaging of Lipid-Shelled Microbubbles for Ultrasound-Triggered Release of Xenon.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Xenon Encapsulation in Liposomes, Nanobubbles, and Microbubbles: Delivery Strategies, Preclinical Evidence, and Translational Barriers.Pharmaceutics · 2026Review
- Ultrasound technology assisted colloidal nanocrystal synthesis and biomedical applications.Ultrasonics sonochemistry · 2024Review
- Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches.Materials advances · 2022Review
- Can Ultrasound-Guided Xenon Delivery Provide Neuroprotection in Traumatic Brain Injury?Neurotrauma reports · 2022Article
- Diagnosis of Atherosclerotic Plaques Using Vascular Endothelial Growth Factor Receptor-2 Targeting Antibody Nano-microbubble as Ultrasound Contrast Agent.Computational and mathematical methods in medicine · 2022Article
- Multivariable Dependence of Acoustic Contrast of Fluorocarbon and Xenon Microbubbles under Flow.Ultrasound in medicine & biology · 2021Article
- Cavitation Emissions Nucleated by Definity Infused through an EkoSonic Catheter in a Flow Phantom.Ultrasound in medicine & biology · 2021Article
- Ultrasound Responsive Noble Gas Microbubbles for Applications in Image-Guided Gas Delivery.Advanced healthcare materials · 2020Article
- Temporal stability of lipid-shelled microbubbles during acoustically-mediated blood-brain barrier opening.Frontiers in physics · 2020Article
- Bactericidal Activity of Lipid-Shelled Nitric Oxide-Loaded Microbubbles.Frontiers in pharmacology · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Xenon (Xe) is a bioactive gas capable of reducing and stabilizing neurologic injury in stroke. The goal of this work was to develop lipid-shelled microbubbles for xenon loading and ultrasound-triggered release. Microbubbles loaded with either xenon (Xe-MB) or xenon and octafluoropropane (Xe-OFP-MB) (9:1 v/v) were synthesized by high-shear mixing. The size distribution and the frequency-dependent attenuation coefficient of Xe-MB and Xe-OFP-MB were measured using a Coulter counter and a broadband acoustic attenuation spectroscopy system, respectively. The Xe dose was evaluated using gas chromatography/mass spectrometry. The total Xe doses in Xe-MB and Xe-OFP-MB were 113.1 ± 13.5 and 145.6 ± 25.5 μl per mg of lipid, respectively. Co-encapsulation of OFP increased the total xenon dose, attenuation coefficient, microbubble stability (in an undersaturated solution), and shelf life of the agent. Triggered release of gas payload was demonstrated with 6-MHz duplex Doppler and 220-kHz pulsed ultrasound. These results constitute the first step toward the use of lipid-shelled microbubbles for applications such as neuroprotection in stroke.
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Registered trials
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