Evidence map›Paper›PMID 31020492›Full record

ArticleMolecular and cellular biochemistry2019

Biological effects of cyclosporin A on CD3

Aravinthan Adithan, Judith Sharmila John Peter, Mohammad Amjad Hossain, Chang-Won Kang, Bumseok Kim, Nam Soo Kim, Ki-Chul Hwang, Jong-Hoon Kim

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aravinthan AdithanCollege of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan, Jeollabuk-Do, Republic of Korea.ORCID http://orcid.org/0000-0001-7086-2616
Judith Sharmila John PeterCollege of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan, Jeollabuk-Do, Republic of Korea.
Mohammad Amjad HossainCollege of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan, Jeollabuk-Do, Republic of Korea.
Chang-Won KangCollege of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan, Jeollabuk-Do, Republic of Korea.
Bumseok KimCollege of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan, Jeollabuk-Do, Republic of Korea.
Nam Soo KimCollege of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan, Jeollabuk-Do, Republic of Korea.
Ki-Chul HwangDepartment of Medicine, College of Medicine, Catholic Kwandong University, Gangneung, Republic of Korea.
Jong-Hoon KimCollege of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan, Jeollabuk-Do, Republic of Korea. jhkim1@jbnu.ac.kr.
Jeonbuk National University · KRCatholic Kwandong University · KR

Funding

National Research Foundation of Korea 2017R1D1A3B03029075
6 · The paper itself

Abstract

Cyclosporin A (CSA) is a widely used drug to prevent the immune cell function. It is well known that CSA blocks transcription of cytokine genes in activated T cells. The connection between T cells and CSA has been well established. However, the effect of CSA on natural killer (NK) cells is not thoroughly understood. Therefore, in the present study, splenocytes and peripheral blood mononuclear cells (PBMCs) were treated with CSA in the presence of concanavalin A (Con A) or interleukin-2 (IL-2). CSA at higher concentrations induces apoptosis and inhibition of proliferation, while lower concentrations showed synergistically enhanced proliferation in splenocytes and PBMCs. Further, CSA favored the in vitro conversion of CD3

Indexed as

AnimalsApoptosisCD3 ComplexCell ProliferationConcanavalin ACyclosporineDose-Response Relationship, DrugGene Expression RegulationGranzymesHumansInterleukin-2K562 CellsKiller Cells, NaturalMaleNatural Cytotoxicity Triggering Receptor 2Natural Cytotoxicity Triggering Receptor 3CD3 ComplexConcanavalin ACyclosporineGranzymesGzmb protein, mouseInterleukin-2Natural Cytotoxicity Triggering Receptor 2Natural Cytotoxicity Triggering Receptor 3NK Cell Lectin-Like Receptor Subfamily BConcanavalin ACyclosporin AImmune suppressionPBMCsProliferationSplenocytes

Identifiers

PMID31020492
OpenAlexW2941667200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.