Evidence map›Paper›PMID 31020485›Full record

ArticleSleep & breathing = Schlaf & Atmung2019

Laryngopharyngeal reflux and dysphagia in patients with obstructive sleep apnea: is there an association?

Fabio Caparroz, Milena Campanholo, Renato Stefanini, Tatiana Vidigal, Leonardo Haddad, Lia Rita Bittencourt, Sergio Tufik, Fernanda Haddad

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Non-acid reflux and sleep apnea: the importance of drug induced sleep endoscopy.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2021
    Article
  9. Observational
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fabio CaparrozDepartment of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil. f_caparroz@hotmail.com.ORCID http://orcid.org/0000-0003-4585-714X
Milena CampanholoDepartment of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil.
Renato StefaniniDepartment of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil.
Tatiana VidigalDepartment of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil.
Leonardo HaddadDepartment of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil.
Lia Rita BittencourtDepartment of Psychobiology, Instituto do Sono, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil.
Sergio TufikDepartment of Psychobiology, Instituto do Sono, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil.
Fernanda HaddadDepartment of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil.
Universidade Federal de São Paulo · BRInstituto do Sono · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is evidence that patients with obstructive sleep apnea (OSA) tend to have a high prevalence of laryngopharyngeal reflux (LPR) and dysphagia. These diseases are known to share the same risk factors and may be interrelated, but there is a lack of studies evaluating their co-occurrence.

objectivesTo evaluate whether the presence of signs and symptoms suggestive of LPR may be associated with the presence of dysphagia in patients with moderate and severe obstructive sleep apnea (OSA), as well as assess the additional impact of these diseases on quality of life in patients with OSA.

methodsSeventy adult patients with moderate or severe OSA were included in the study. The RSI (Reflux Symptom Index) and Swallowing Quality of Life (SWAL-QOL) in dysphagia questionnaires were administered, laryngoscopy was performed to calculate the Reflux Finding Score (RFS), and fiber-optic endoscopic evaluation of swallowing (FEES) was conducted.

resultsThe prevalence of LPR was 59.7%, and the prevalence of dysphagia was 27.3%. The association between LPR and dysphagia was present in 17.9% of patients, but with no statistically significant difference. Lower SWAL-QOL scores were observed in several domains in patients with LPR and in only one domain in patients with evidence of dysphagia on FEES.

conclusionsAlthough 17.9% of patients presented with findings suggestive of concomitant LPR and dysphagia, there was no statistically significant association between these two conditions. Patients with LPR had worse scores in several domains of dysphagia-related quality of life, while FEES evidence of dysphagia was associated with worse quality of life in only one domain.

Indexed as

AdultBrazilCorrelation of DataCross-Sectional StudiesDeglutition DisordersEndoscopyFemaleHumansLaryngopharyngeal RefluxMaleMiddle AgedPrevalenceSleep Apnea, ObstructiveSleepinessSurveys and QuestionnairesDysphagiaLaryngopharyngeal refluxObstructive sleep apnea

Identifiers

PMID31020485
OpenAlexW2940550769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.