Evidence map›Paper›PMID 31020463›Full record

ArticleEndocrine2019

Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways.

Hong Weng Pang, Andrea Linares, Leena Couling, Jessica Santollo, Leonardo Ancheta, Derek Daniels, Robert C Speth

Open access · greenAbstract read
In one paragraph

Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Insights Into the Role of Angiotensin-II ATHypertension (Dallas, Tex. : 1979) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Hong Weng PangCollege of Pharmacy, Nova Southeastern University, Ft. Lauderdale, FL, 33328, USA.
Andrea LinaresCollege of Pharmacy, Nova Southeastern University, Ft. Lauderdale, FL, 33328, USA.
Leena CoulingCollege of Pharmacy, Nova Southeastern University, Ft. Lauderdale, FL, 33328, USA.
Jessica SantolloBehavioral Neuroscience Program, Department of Psychology, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Leonardo AnchetaAdvanced Targeting Systems, 10451 Roselle St. #300, San Diego, CA, 92121, USA.
Derek DanielsBehavioral Neuroscience Program, Department of Psychology, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Robert C SpethCollege of Pharmacy, Nova Southeastern University, Ft. Lauderdale, FL, 33328, USA. RS1251@nova.edu.ORCID 0000-0002-6434-2136
Nova Southeastern University · USAdvanced Targeting Systems (United States) · USGeorgetown University · USUniversity at Buffalo, State University of New York · USUniversity of Kentucky · US

Funding

Supplement for Kentucky BIRCWH Program: Training the Next Generation of Women's Health Scholars: Dr. ConnerK12DA035150 · NIDA · UNIVERSITY OF KENTUCKY · PI Thomas E Curry · 2012 to 2026
$9.0M
Development of a radioligand for assay of angiotensin-converting enzyme-2(ACE-2)R15HL113905 · NHLBI · NOVA SOUTHEASTERN UNIVERSITY · PI SPETH, ROBERT CHARLES · 2013 to 2013
$436k
NHLBI NIH HHS R15 HL113905NIDA NIH HHS K12 DA035150
6 · The paper itself

Abstract

purposeTo study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT

methodsAngiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT

resultsThe BSA-Ang II conjugate was less potent competing for AT

conclusionsAddition of a high molecular weight molecule to Ang II reduced its AT

Indexed as

Adrenal CortexAldosteroneAngiotensin IIAnimalsbeta-ArrestinsCalcium SignalingCell Line, TumorDrinkingHumansLiverMaleRatsRats, Sprague-DawleyReceptor, Angiotensin, Type 1Serum Albumin, BovineSignal TransductionAldosteroneAngiotensin IIbeta-ArrestinsReceptor, Angiotensin, Type 1Serum Albumin, BovineAldosterone releaseAT1 receptorBiased agonismBovine serum albumin-conjugated angiotensin IICalcium mobilizationSalt appetite

Identifiers

PMID31020463
PMCPMC7901354
OpenAlexW2942479707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.