Evidence map›Paper›PMID 31020441›Full record

Observational studyClinical and experimental nephrology2019

The interaction between post-transplant anemia and allograft function in kidney transplantation: The Japan Academic Consortium of Kidney Transplantation-II study.

Masayoshi Okumi, Yasuhiro Okabe, Kohei Unagami, Yoichi Kakuta, Junpei Iizuka, Toshio Takagi, Hiroki Shirakawa, Tomokazu Shimizu, Kazuya Omoto, Hideki Ishida and 3 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical and experimental nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Characteristic changes in blood routine and peripheral blood lymphocyte subpopulations in recipients of different types of rejection.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Masayoshi OkumiDepartment of Urology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan. okumi@twmu.ac.jp.ORCID http://orcid.org/0000-0001-7443-2621
Yasuhiro OkabeDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kohei UnagamiDepartment of Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Yoichi KakutaDepartment of Urology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan.
Junpei IizukaDepartment of Urology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan.
Toshio TakagiDepartment of Urology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan.
Hiroki ShirakawaDepartment of Urology, Ohkubo Hospital, Tokyo, Japan.
Tomokazu ShimizuDepartment of Urology, Toda Chuo General Hospital, Saitama, Japan.
Kazuya OmotoDepartment of Urology, Toda Chuo General Hospital, Saitama, Japan.
Hideki IshidaDepartment of Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Masafumi NakamuraDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kazunari TanabeDepartment of Urology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan.
Japan Academic Consortium of Kidney Transplantation (JACK)
Tokyo Women's Medical University · JPKyushu University · JPSocial Insurance Saitama Chuo Hospital · JPOhkubo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interaction between post-transplant anemia (PTA) and allograft function in kidney transplantation has not been evaluated directly. PTA, defined by WHO/AST criteria, was investigated in 1307 adult kidney transplant recipients between 2000 and 2015 (median follow-up, 7 years).

methodsWe investigated the impact of hemoglobin (Hb) on graft failure (non-censored for death) and their interactions, time-dependent Cox model, and subgroup analysis were used.

resultsPTA prevalence was 43.6% at 7 years and varied according to allograft function, recipient sex, and follow-up period. Decreased Hb considering the time-varying effect was associated with an increased risk of graft failure (hazard ratio = 1.83, 95% CI 1.66-2.02, P < 0.001). In subgroup analysis, allograft function (post-transplant time-averaged estimated glomerular filtration rate and cut point: 45 mL/min/1.73 m

conclusionsThe unfavorable impact of PTA was significantly enhanced by low allograft function. PTA is likely to be associated with graft failure due to interaction with allograft function. Therefore, we should consider both Hb level and allograft function while determining the treatment strategy.

Indexed as

Graft SurvivalAdultAnemiaBiomarkersFemaleGlomerular Filtration RateHemoglobinsHumansJapanKidney TransplantationMaleMiddle AgedPrevalenceRetrospective StudiesRisk AssessmentRisk FactorsBiomarkersHemoglobinsAllograft functionConfoundingInteractionKidney transplantationPost-transplant anemia

Identifiers

PMID31020441
OpenAlexW2940957226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.