ArticleAnnals of intensive care2019
Determinants of Doppler-based renal resistive index in patients with septic shock: impact of hemodynamic parameters, acute kidney injury and predisposing factors.
Article in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04693923 (Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients), which is not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients: Pathophysiological Determinants, and Relation to Changes in Systemic, Regional and Microcirculatory Blood Flow
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Renal resistive index-guided mean arterial pressure titration in sepsis: a prospective single-center, single-blind, parallel-group randomized controlled trial.Nature communications · 2026Trial
- Effects of changes in position, positive end-expiratory pressure and mean arterial pressure on renal, portal and hepatic Doppler ultrasound perfusion indices: a randomized crossover study in cardiac surgery patients.Journal of clinical monitoring and computing · 2022Trial
- ARISE framework: a temporal, multi-organ view of perfusion in sepsis.Internal and emergency medicine · 2026Review
- Less-Invasive Hemodynamic and Tissue Perfusion Monitoring in Sepsis and Septic Shock: A Narrative Review.Journal of clinical medicine · 2026Review
- Quantification of Kidney Inflammation Using Nanobubble-mediated Contrast Enhanced Ultrasound.Nanotheranostics · 2026Article
- Ultrasonic hemodynamic parameters for predicting acute kidney injury and establishment of a predictive model based on these parameters.International urology and nephrology · 2026Observational
- Investigation of 22q11.2 Deletion Syndrome in the first Moroccan Pediatric Patients series.La Tunisie medicale · 2025Article
- Observational
- Association between the mean perfusion pressure and the risk of acute kidney injury in critically ill patients with sepsis: a retrospective cohort study.BMC infectious diseases · 2024Article
- Renal Arterial and Venous Doppler in Cardiorenal Syndrome: Pathophysiological and Clinical Insights.Biomedicines · 2024Review
- Wearable bioadhesive ultrasound shear wave elastography.Science advances · 2024Article
- Influence of arterial blood gases on the renal arterial resistive index in intensive care unit.Journal of translational medicine · 2023Observational
- Renal venous density in the arterial phase of contrast-enhanced CT predicts prognosis in septic shock.The British journal of radiology · 2023Article
- Renal hemodynamic evaluation protocol based on the pathophysiological mechanism of acute kidney injury: Critical Care UltraSound Guided-ARenal failure · 2023Review
- Performance of the renal resistive index and usual clinical indicators in predicting persistent AKI.Renal failure · 2022Article
- Shock Resuscitation - the Necessity and Priority of Renal Blood Perfusion Assessment.Aging and disease · 2022Article
- Fiber scaffold bioartificial liver therapy relieves acute liver failure and extrahepatic organ injury in pigs.Theranostics · 2021Article
- Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study.Frontiers in medicine · 2021Article
- Application of Critical Care Ultrasound in Patients With COVID-19: Our Experience and Perspective.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Feasibility of renal resistive index measurements performed by an intermediate and novice sonographer in a volunteer population.The ultrasound journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased renal resistive index (RI) measured by Doppler ultrasonography has been shown to be associated with acute kidney injury (AKI) in septic patients. However, its clinical use is limited by poor sensitivity and specificity which may be explained by its numerous determinants [in particular mean arterial pressure (MAP)]. We measured, in patients with septic shock, RI at different MAP levels over a short period of time on the admission day to ICU (D1) and every 3 days until day 10 (D10) to define the determinants of RI and study specifically the relationship between RI and MAP.
resultsConsecutive patients with septic shock without preexisting chronic renal dysfunction were included in this prospective cohort study in two ICUs. Sixty-five patients were included in the study. Thirty-three (50.8%) and 15 (23.1%) patients had a history of chronic hypertension or diabetes, respectively. At D3, 35 patients presented AKI with AKIN 2 or 3 criteria (severe AKI, AKIN2-3 group) and 30 presented no AKIN or AKIN 1 criteria (AKIN0-1 group). As previously described, RI at D1 was higher in the AKIN2-3 group than in the AKIN0-1 group (0.73 interquartile range [0.67; 0.78] vs. 0.67 [0.59; 0.72], p = 0.001). A linear mixed model for predicting RI from D1 to D10 showed that an increase in pulse pressure, presence of severe AKI and additional day of ICU hospitalization were associated with an increase in RI. An increase in MAP and recovery from severe AKI were associated with a decrease in RI. In the presence of chronic hypertension or diabetes, an increase in MAP resulted in a lower decrease in RI, than in the absence of such factors. Presence of AKI at D3 did not impact the relationship between MAP and RI.
conclusionsSevere AKI was associated with a reversible increase in RI without significant interaction with the relationship between MAP and RI. Conversely, the presence of chronic hypertension and/or diabetes interacted with this relationship.
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