ArticleMolecular genetics and genomics : MGG2019
Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia.
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Article in Molecular genetics and genomics : MGG, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- TRIAGE: an R package for regulatory gene analysis.Briefings in bioinformatics · 2025Article
- Low Expression of SCN4B Predicts Poor Prognosis in Non-small Cell Lung Cancer.Current cancer drug targets · 2025Article
- The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells.Cells · 2021Article
- Identification of key methylation differentially expressed genes in posterior fossa ependymoma based on epigenomic and transcriptome analysis.Journal of translational medicine · 2021Article
- Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaFrontiers in physiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 6 institutions in 2 countries.
Qin YangState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Hongbo XiongKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Chengqi XuKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Yuan HuangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Xin TuKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Gang WuRenmin Hospital, Wuhan University, Wuhan, People's Republic of China.
Fenfen FuKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Zhijie WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Longfei WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Yuanyuan ZhaoKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Sisi LiKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Yufeng HuangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Chuchu WangSchool of Life Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, People's Republic of China.
Dan WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Yufeng YaoKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Fan WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Yongbo WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Yu XueKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Pengyun WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
Qiuyun ChenDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. chenq3@ccf.org.
Jielin PuDepartment of Cardiology, East Hospital, Tongji University, Shanghai, Beijing, 100037, People's Republic of China. jielinpu@sina.cn.
Qing K WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China. qkwang@hust.edu.cn.
Huazhong University of Science and Technology · CNCleveland Clinic Lerner College of Medicine · USShanghai East Hospital · CNShanghai Jiao Tong University · CNWuhan University · CNZhengzhou University · CN
Funding
NGS in Large CAD Families: In-Depth Identification of Rare Risk Genomic VariantsR01HL121358 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, QING KENNETH · 2014 to 2017
$2.8MTargeting Nav1.5 trafficking as a therapy for lethal genetic cardiac arrhythmiasR01HL126729 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, QING KENNETH · 2015 to 2018
$1.6MTargeting a novel AGGF1 signaling pathway for therapy of pulmonary hypertensionR01HL138465 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI CHEN, QIUYUN, WANG, QING KENNETH · 2019 to 2019
$559kHubei Province's Innovative Team grant 2017CFA014National Natural Science Foundation of China 81630002National Natural Science Foundation of China (CN) 31430047NHLBI NIH HHS R01 HL121358NHLBI NIH HHS R01 HL126729NHLBI NIH HHS R01 HL138465NIH/NHLBI grants R01 HL126729
Abstract
Ventricular tachycardia (VT) causes sudden cardiac death, however, the majority of risk genes for VT remain unknown. SCN4B encodes a β-subunit, Na
Indexed as
Amino Acid SubstitutionAdultAgedCase-Control StudiesDown-RegulationFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHEK293 CellsHumansMaleMiddle AgedSequence Analysis, DNATachycardia, VentricularVoltage-Gated Sodium Channel beta-4 SubunitSCN4B protein, humanVoltage-Gated Sodium Channel beta-4 SubunitCardiac sodium channel β4 subunit (SCN4B, Navβ4)GeneticsSCN5A/Nav1.5Single nucleotide polymorphism (SNP)Ventricular tachycardia (VT)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.