Evidence map›Paper›PMID 31020007›Full record

ArticleAnnals of clinical and translational neurology2019

Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.

Zurab Nadareishvili, Devon Kelley, Marie Luby, Alexis N Simpkins, Richard Leigh, John K Lynch, Amie W Hsia, Richard T Benson, Kory R Johnson, John M Hallenbeck and 1 more

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. SUMOtherapeutics for Ischemic Stroke.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zurab NadareishviliSection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Devon KelleySection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Marie LubySection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Alexis N SimpkinsSection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Richard LeighSection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
John K LynchSection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Amie W HsiaSection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Richard T BensonSection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Kory R JohnsonBioinformatics Section Information Technology Program Division of Intramural Research NINDS NIH Bethesda Maryland.
John M HallenbeckSection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Lawrence L LatourSection on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.

Funding

CLINICAL AND IMAGING CORE SUPPORT OF ACUTE STROKE RESEARCHZICNS003044 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LATOUR, LAWRENCE · 2015 to 2025
$32.8M
NOVEL INSIGHTS INTO CEREBRAL ISCHEMIC PATHOPHYSIOLOGY IN HUMANSZIANS003043 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LATOUR, LAWRENCE · 2009 to 2025
$19.5M
6 · The paper itself

Abstract

We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion-diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion-diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (

Indexed as

AgedAged, 80 and overBrainBrain IschemiaCerebrovascular CirculationDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedResearch DesignStroke

Identifiers

PMID31020007
PMCPMC6469246

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.