ArticleAnnals of clinical and translational neurology2019
Investigation of white matter PiB uptake as a marker of white matter integrity.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Translational molecular imaging and drug development in multiple sclerosis.Theranostics · 2026Review
- Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI.Fluids and barriers of the CNS · 2025Article
- FDG-PET versus Amyloid-PET Imaging for Diagnosis and Response Evaluation in Alzheimer's Disease: Benefits and Pitfalls.Diagnostics (Basel, Switzerland) · 2023Article
- Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Innate immune cells and myelin profile in multiple sclerosis: a multi-tracer PET/MR study.European journal of nuclear medicine and molecular imaging · 2022Article
- Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer's disease.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022Article
- Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Article
- The Role of Molecular Imaging as a Marker of Remyelination and Repair in Multiple Sclerosis.International journal of molecular sciences · 2021Review
- Reduced [European journal of nuclear medicine and molecular imaging · 2021Article
- Impact of Age on Multiple Sclerosis Disease Activity and Progression.Current neurology and neuroscience reports · 2020Review
- Amyloid Precursor Protein Variant, E665D, Associated With Unique Clinical and Biomarker Phenotype.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
objectiveTo investigate the associations of Pittsburgh compound-B (PiB) uptake in white matter hyperintensities (WMH) and normal appearing white matter (NAWM) with white matter (WM) integrity measured with DTI and cognitive function in cognitively unimpaired older adults.
methodsCognitively unimpaired older adults from the population-based Mayo Clinic Study of Aging (
resultsThe WMH PiB SUVr was lower than NAWM PiB SUVr (
interpretationReduced PiB uptake in the WMH is associated with a loss of WM integrity and cognitive function after accounting for the global cortical PiB uptake, suggesting that WM PiB uptake may be an early biomarker of WM integrity that precedes cognitive impairment in older adults. When using WM as a reference region in cross-sectional analysis of PiB SUVr, individual variability in WMH volume as well as age should be considered.
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