ArticleAnnals of translational medicine2019
Probiotics improve glucose and lipid metabolism in pregnant women: a meta-analysis.
Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 12 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
26 citing papers in PubMed, 12 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- The Influences of Oral Probiotics on the Immunometabolic Response During Pregnancy and Lactation: A Systematic Review.Nutrients · 2025Pooled it
- The effect of probiotics on gestational diabetes mellitus: an umbrella meta-analysis.BMC endocrine disorders · 2024Pooled it
- Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomised controlled trials.Journal of global health · 2024Pooled it
- The effects of prebiotic, probiotic or synbiotic supplementation on overweight/obesity indicators: an umbrella review of the trials' meta-analyses.Frontiers in endocrinology · 2024Pooled it
- Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis.Renal failure · 2022Pooled it
- Pooled it
- The effect of probiotics on gestational diabetes and its complications in pregnant mother and newborn: A systematic review and meta-analysis during 2010-2020.Journal of clinical laboratory analysis · 2022Pooled it
- Microbiome alterations in women with gestational diabetes mellitus and their offspring: A systematic review.Frontiers in endocrinology · 2022Pooled it
- Preventive effect of probiotics supplementation on occurrence of gestational diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2022Pooled it
- Pooled it
- Pooled it
- Paocai-derived Lactiplantibacillus plantarum NMG11 can maintain lipid metabolic homeostasis, alleviate inflammation, and remodel the gut microbiota in high-cholesterol diet-fed mice.Probiotics and antimicrobial proteins · 2026Article
- Unveiling the probiotic potential ofAIMS microbiology · 2026Article
- Gestational Diabetes Mellitus: Efficacy of Non-Pharmacological Interventions for Management and Prevention.Healthcare (Basel, Switzerland) · 2025Review
- Probiotic Supplementation during Pregnancy: Evaluating the Current Clinical Evidence against Gestational Diabetes Mellitus.Current diabetes reviews · 2025Review
- Gestational diabetes mellitus - more than the eye can see - a warning sign for future maternal health with transgenerational impact.Frontiers in clinical diabetes and healthcare · 2025Review
- Review
- Article
- The Importance of a Healthy Microbiome in Pregnancy and Infancy and Microbiota Treatment to Reverse Dysbiosis for Improved Health.Antibiotics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to assess the effects of probiotic supplementation on the maternal metabolism and the risk of development of gestational diabetes mellitus (GDM) in the pregnant women by a meta-analysis of relevant randomized controlled trials (RCTs).
methodsThe medical literature was searched from PubMed, Web of Science and the Cochrane Library since inception to October 2017. Two investigators independently performed the data extraction and quality assessment. The mean differences (MD) or standardized mean differences (SMD) or relative risk (RR) with 95% confidence intervals (CIs) were calculated with the random-effects model.
resultsFrom 648 citations, a total of ten RCTs published in 13 articles with 1,139 participants met the inclusion criteria. The meta-analysis showed that probiotics supplementation effectively reduced the fasting blood glucose (FBG) levels (MD -0.11 mmol/L, P=0.0003), serum insulin levels (MD -2.06 µU/mL, P<0.00001), insulin resistance (HOMA-IR) (MD -0.38, P<0.00001). The study found a significant effect of probiotics on decreasing the risk of GDM [risk ratio (RR) 0.52, P=0.003) in early pregnancy. Additionally, there were statistically significant reductions in the total cholesterol and triglycerides levels after probiotic interventions (SMD -0.56, P=0.03; SMD -0.66, P=0.04), respectively.
conclusionsOur study shows that the probiotic use was associated with improved glucose and lipid metabolism in the pregnant women, and might also contribute to the reduced risk of GDM.
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Registered trials
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