Evidence map›Paper›PMID 31019915›Full record

ReviewMolecular neuropsychiatry2019

Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder.

Anton Schulmann, Euijung Ryu, Vanessa Goncalves, Brandi Rollins, Michael Christiansen, Mark A Frye, Joanna Biernacka, Marquis P Vawter

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular neuropsychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  7. Review
  8. Research progress in mitochondrial quality control in schizophrenia.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Anton SchulmannJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.
Euijung RyuDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Vanessa GoncalvesMolecular Brain Science Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Brandi RollinsFunctional Genomics Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, California, USA.
Michael ChristiansenDepartment for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Joanna BiernackaDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Marquis P VawterFunctional Genomics Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, California, USA.
Mayo Clinic in Florida · USUniversity of California, Irvine · USCentre for Addiction and Mental Health · CAHoward Hughes Medical Institute · USStatens Serum Institut · DKWinnMed · US

Funding

Mitochondrial Dysfunction In SchizophreniaR01MH085801 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAWTER, MARQUIS PHILIP · 2009 to 2020
$5.0M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059545 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 1998 to 2007
$2.6M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059553 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1998 to 2007
$2.1M
Mapping genes that contribute to bipolar disorderZ01MH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2003 to 2008
$2.0M
Collaborative Genomic Study of Bipolar DisorderR01MH059548 · NIMH · UNIVERSITY OF IOWA · PI CORYELL, WILLIAM HENRY · 1998 to 2007
$1.9M
COLLABORATIVE STUDY OF BIPOLAR DISORDERR01MH059535 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S · 1998 to 2007
$1.9M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059567 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 1998 to 2007
$1.8M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059556 · NIMH · RUSH UNIVERSITY MEDICAL CENTER · PI SCHEFTNER, WILLIAM A · 1998 to 2007
$1.6M
Intramural NIH HHS Z01 MH002810NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059545NIMH NIH HHS R01 MH059548NIMH NIH HHS R01 MH059553NIMH NIH HHS R01 MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068NIMH NIH HHS R01 MH085801
6 · The paper itself

Abstract

Mitochondrial dysfunction has been associated with schizophrenia (SZ) and bipolar disorder (BD). This review examines recent publications and novel associations between mitochondrial genes and SZ and BD. Associations of nuclear-encoded mitochondrial variants with SZ were found using gene- and pathway-based approaches. Two control region mitochondrial DNA (mtDNA) SNPs, T16519C and T195C, both showed an association with SZ and BD. A review of 4 studies of A15218G located in the cytochrome B oxidase gene (CYTB, SZ = 11,311, control = 35,735) shows a moderate association with SZ (

Indexed as

Bipolar disorderEpistatic interactionsGenome-wide associationMitochondrial DNAPathway analysisSchizophrenia

Identifiers

PMID31019915
PMCPMC6465701
OpenAlexW2911571221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.