ReviewFrontiers in bioengineering and biotechnology2019
A Review of Structural and Biomechanical Changes in the Cornea in Aging, Disease, and Photochemical Crosslinking.
Review in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Corneal biomechanical property changes following corneal collagen cross-linking in keratoconus: a systematic review and meta-regression analysis.International ophthalmology · 2025Pooled it
- Influence of interleukin 17 A and 17 F polymorphisms in keratoconus.Molecular biology reports · 2021Trial
- Biomechanical changes in keratoconus after customized stromal augmentation.Taiwan journal of ophthalmologyTrial
- Microneedle-based drug delivery for inflammatory and immune-mediated ocular diseases: current applications and future perspectives.Drug delivery · 2026Review
- Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling.Journal of neuroscience research · 2026Review
- Association Between Geriatric Assessment Scores and Corneal Biomechanical Parameters in Patients with Glaucoma.Biomedicines · 2026Article
- Characteristics and Prediction Accuracy According to Corneal Stiffness in Suspected Keratoconus.Journal of clinical medicine · 2026Article
- Sex Hormone Imbalance in Keratoconus: Estrogen-Mediated Collagen Remodeling and Biomechanical Weakening.Investigative ophthalmology & visual science · 2026Article
- Tear Film Inflammatory Biomarkers in Keratoconus: Insights into Disease Severity and Diagnostic Potential.Korean journal of ophthalmology : KJO · 2026Observational
- Comparison of femtosecond laser-assisted corneal relaxing incisions and toric implantable collamer lens for low-to-moderate astigmatism: A retrospective study.Lasers in medical science · 2026Article
- Analysis of Keratoconus-Related Phenotypes in Two Pcsk1 Mouse Models.Translational vision science & technology · 2026Article
- In Vivo Biomechanical Characteristics of Human Corneas With Phase-Decorrelation OCT.Investigative ophthalmology & visual science · 2026Article
- Layer-Specific Proteomic Profiling of the Human Cornea Reveals Insights Into Structure and Biological Function.Investigative ophthalmology & visual science · 2026Article
- Corneal Biomechanics in Glaucoma: Current Evidence for Diagnosis, Risk Stratification, and Prognosis.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Collagen Mechanics.Sub-cellular biochemistry · 2026Review
- Tear MicroRNA-Based Molecular Signature for Keratoconus Stratification: A Cross-Cohort Integration Study.Bioinformatics and biology insights · 2026Article
- Progressive Insights into 3D Bioprinting for Corneal Tissue Restoration.Advanced healthcare materials · 2026Review
- A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis.Scientific reports · 2025Article
- Spontaneous refractive error, ocular biometry and age related lens changes in a population of geriatric rhesus macaques.Scientific reports · 2025Article
- Effects of customized corneal cross-linking on higher-order aberrations in progressive keratoconus and low-grade myopia.Acta ophthalmologica · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The study of corneal biomechanics is motivated by the tight relationship between biomechanical properties and visual function within the ocular system. For instance, variation in collagen fibril alignment and non-enzymatic crosslinks rank high among structural factors which give rise to the cornea's particular shape and ability to properly focus light. Gradation in these and other factors engender biomechanical changes which can be quantified by a wide variety of techniques. This review summarizes what is known about both the changes in corneal structure and associated changes in corneal biomechanical properties in aging, keratoconic, and photochemically crosslinked corneas. In addition, methods for measuring corneal biomechanics are discussed and the topics are related to both clinical studies and biomechanical modeling simulations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.