Evidence map›Paper›PMID 31019876›Full record

ArticleAnalytical cellular pathology (Amsterdam)2019

Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation.

Kristin Mai, Andreas Boldt, Hans-Michael Hau, Michael Kirschfink, Stephan Schiekofer, Frieder Keller, Joachim Beige, Athanassios Giannis, Ulrich Sack, Franz Maximilian Rasche

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristin MaiInstitute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.
Andreas BoldtInstitute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.
Hans-Michael HauDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital Leipzig, Leipzig, Germany.
Michael KirschfinkInstitute of Immunology, University of Heidelberg, Heidelberg, Germany.
Stephan SchiekoferCenter for Geriatric Medicine, Bezirksklinikum Regensburg, Regensburg, Germany.
Frieder KellerMedical Department I, Nephrology Division, University Hospital Ulm, Ulm, Germany.
Joachim BeigeDepartment of Nephrology, KfH Renal Unit, Hospital St. Georg, Leipzig, Germany.
Athanassios GiannisInstitute for Organic Chemistry, University of Leipzig, Leipzig, Germany.
Ulrich SackInstitute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.ORCID 0000-0002-7813-0492
Franz Maximilian RascheDepartment of Internal Medicine, Neurology and Dermatology, Clinic for Endocrinology and Nephrology, Section of Nephrology, University Hospital Leipzig, Leipzig, Germany.ORCID 0000-0003-4299-8254

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic or intercurrent alterations of the immune system in patients with end-stage renal disease (CKD) and intermittent hemodialysis (CKD5D, HD) have been attributed to an acute rejection of renal allograft.

methodsLeukocyte subsets in flow cytometry, complement activation, and concentrations of TGF

resultsBefore HD, the median proportion of CD8+ effector cells, CD8+ CCR5+ effector cells, and HLA-DR+ regulatory T cells as well as the median concentration of soluble CD30 increased and naive CD8+ T cells decreased. During HD, there was a significant decrease in CD4- CD8- T cells (

conclusionHD might interact with the allograft outcome by influencing T cell subsets and activation of the complement system in a biphasic course.

Indexed as

AdultAgedCD8-Positive T-LymphocytesEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansInterleukin-2 Receptor alpha SubunitInterleukinsKidney TransplantationLeukocytesMaleMiddle AgedRenal DialysisT-LymphocytesYoung AdultInterleukin-2 Receptor alpha SubunitInterleukins

Identifiers

PMID31019876
PMCPMC6452532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.