Evidence map›Paper›PMID 31019678›Full record

ArticleTherapeutic advances in drug safety2019

Influence of pharmacist intervention on drug safety of geriatric inpatients: a prospective, controlled trial.

Angela Nachtigall, Hans J Heppner, Petra A Thürmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in drug safety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Angela NachtigallDepartment of Human Medicine, University of Witten/Herdecke, Witten, Germany, Pharmacy, Helios Clinic Schwelm, Schwelm, Germany.
Hans J HeppnerDepartment of Human Medicine, University of Witten/Herdecke, Witten, Germany Department of Geriatric Medicine, Helios Clinic Schwelm, Schwelm, Germany, Institute for Biomedicine of Ageing, FAU Erlangen-Nuremberg, Nuremberg, Germany.
Petra A ThürmannDepartment of Human Medicine, University of Witten/Herdecke, Witten, Germany Department of Geriatric Medicine, Helios Clinic Schwelm, Schwelm, Germany, Institute for Biomedicine of Ageing, FAU Erlangen-Nuremberg, Nuremberg, Germany.
Witten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDemographic shift leads to an increasing number of geriatric patients suffering from multimorbidity and resulting polypharmacy. Polypharmacy is shown to be associated with drug-related problems (DRPs) and increased morbidity. For Germany, a hospital-based intervention may be successful optimizing of polypharmacy. The aim of this study was to reduce DRPs in geriatric inpatients by a structured pharmacist's intervention and to measure the acceptance rate of pharmaceutical recommendations.

methodsThis study followed an open, prospective, quasi-randomized, controlled design and was conducted in a geriatric department in a teaching hospital in Germany. Patients of all sexes were included, with a minimum age of 70 years, a written informed consent and a regular intake of at least five drugs daily. Primary outcome was the percentage of patients having a DRP at admission and discharge. A DRP was defined as a prescription without indication or a relevant drug-drug interaction or prescription of a potentially inappropriate medication or presence of an adverse drug reaction. Recommendations were classified and discussed face to face. Statistical analyses were performed using a full-set analysis and a matched-pairs design.

resultsWithin 12 months, 411 patients were recruited with median age of 82 years (intervention:

conclusionThis prospective controlled trial showed that a pharmacist's intervention was successful in optimizing polypharmacy in geriatric inpatients.

Indexed as

drug safetygeriatric inpatientsmedication appropriateness indexpharmaceutical interventionpolypharmacypotentially inappropriate medication

Identifiers

PMID31019678
PMCPMC6469284
OpenAlexW2937849083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.