ArticleJournal of clinical medicine research2019
Prolonged Rupture of Membranes, Neonatal Outcomes and Management Guidelines.
Article in Journal of clinical medicine research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The burden of neonatal sepsis and its risk factors in Africa. a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Factors Associated with Severe Respiratory Support Requirement in Neonates with Gram-Negative Infections: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Prevalence, Maternal Risk Factors, and Neonatal Outcomes of Early-Onset Neonatal Septicemia: A Retrospective Study.Cureus · 2026Article
- Maternal and neonatal determinants of newborn sepsis: A case-control study in resource-limited settings.World journal of clinical pediatrics · 2026Article
- Sex Differences in Wheezing During the First Three Years of Life After Delivery via Caesarean Section.Children (Basel, Switzerland) · 2025Article
- Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study.Scientific reports · 2025Article
- Clinical prediction models to diagnose neonatal sepsis in low-income and middle-income countries: a scoping review.BMJ global health · 2025Article
- The impact of premature rupture of membrane on neonatal outcomes in infants born at 34 weeks gestation or later.Journal of the Chinese Medical Association : JCMA · 2024Article
- Agreement between an Early-Onset Neonatal Sepsis Risk Calculator and the Colombian Clinical Practice Guideline in Three Tertiary-Care Centers in Bogotá, Colombia.American journal of perinatology · 2024Observational
- Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study.Children (Basel, Switzerland) · 2024Article
- Neonatal Sepsis: Aetiology, Pathophysiology, Diagnostic Advances and Management Strategies.Clinical medicine insights. Pediatrics · 2024Review
- Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis.Frontiers in medicine · 2024Article
- Pattern of Inflammatory Markers and Use of Antibiotics in Meconium Aspiration Syndrome: A Retrospective Cohort Study.Cureus · 2023Article
- Article
- Diagnosing early-onset neonatal sepsis in low-resource settings: development of a multivariable prediction model.Archives of disease in childhood · 2023Article
- Risk factors for neonatal sepsis among neonates in the neonatal intensive care unit at Hawassa University Comprehensive Specialized Hospital and Adare General Hospital in Hawassa City, Ethiopia.Frontiers in pediatrics · 2023Article
- Vaccines for Perinatal and Congenital Infections-How Close Are We?Frontiers in pediatrics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlonged rupture of membranes (PROM) is a risk factor for early-onset neonatal sepsis (EOS). In the absence of early specific and sensitive diagnostic tools, management of asymptomatic infants is difficult. This study was conducted to investigate clinical outcomes of newborns born to mothers with PROM.
methodsA retrospective study of neonates ≥ 34 weeks admitted due to PROM was conducted. Medical charts were reviewed. Neonates were classified into three categories based on their status at birth: ill appearing, well, and equivocal. Sepsis risk calculator was retrospectively applied.
resultsA total of 176 neonates were included. All mothers had unknown group B streptococcus (GBS) status. Of them, 74.4% were asymptomatic. Nine infants (5%) had positive cultures, and 23 infants (13%) had culture-negative sepsis. The newborns with sepsis fit into the "ill appearing" category with a significantly higher proportion (12.5% vs. 0.0%, P value < 0.0).
conclusionsReliable early diagnostic tools for neonatal sepsis are lacking. Adopting a protocol that utilizes multiple methods and follow-up for the clinical condition of these infants are the key factors to avoid missing neonates with true sepsis and decreasing the use of antibiotics in those without infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.