Evidence map›Paper›PMID 31019515›Full record

ArticleFrontiers in immunology2019

Development and Optimization of an ELISA to Quantitate C3(H

Michelle Elvington, M Kathryn Liszewski, Alexis R Liszewski, Hrishikesh S Kulkarni, Ramsey R Hachem, Thalachallour Mohanakumar, Alfred H J Kim, John P Atkinson

Open access · goldAbstract readValidation Study
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Emerging roles for complement in lung transplantation.The Journal of clinical investigation · 2025
    Review
  5. Complement C3 Activation in the Human Retinal Pigment Epithelium.Investigative ophthalmology & visual science · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Assessment of the Role of C3(HFrontiers in immunology · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michelle ElvingtonDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
M Kathryn LiszewskiDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Alexis R LiszewskiDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Hrishikesh S KulkarniDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Ramsey R HachemDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Thalachallour MohanakumarNorton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Alfred H J KimDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
John P AtkinsonDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Washington University in St. Louis · USSt. Joseph's Hospital and Medical Center · US

Funding

Washington University Institute of Clinical and Translational Sciences (KL2) KL2TR002346 · NCATS · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 2017 to 2026
$14.0M
Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6M
INTRACELLULAR C3 PROTEINS: SOURCE, COMPOSITION, TRAFFICKING AND FUNCTIONR01GM099111 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2011 to 2019
$2.7M
Complement Activation Signatures in Systemic Lupus Erythematosus: Castle StudyR21AR069833 · NIAMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN, KIM, ALFRED HYOUNGJU · 2017 to 2018
$369k
NCATS NIH HHS KL2 TR002346NIAMS NIH HHS L30 AR072421NIAMS NIH HHS P30 AR073752NIAMS NIH HHS R21 AR069833NIGMS NIH HHS GM0099111NIGMS NIH HHS R01 GM099111
6 · The paper itself

Abstract

Discovery of a C3(H

Indexed as

Arthritis, RheumatoidBiomarkersBronchoalveolar Lavage FluidCase-Control StudiesComplement ActivationComplement C3Enzyme-Linked Immunosorbent AssayGraft RejectionHumansInflammationLung TransplantationLupus Erythematosus, SystemicPrognosisWaterBiomarkersComplement C3WaterautoimmunitybiomarkerC3C3(H2O)complementELISAhuman

Identifiers

PMID31019515
PMCPMC6458276
OpenAlexW2926917558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.