ReviewFrontiers in immunology2019
ILC2s-Trailblazers in the Host Response Against Intestinal Helminths.
Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Enteric nervous system and inflammatory bowel disease.Gastroenterology report · 2026Review
- Adrenergic signaling during parasitic infections.Frontiers in immunology · 2025Review
- Versatile roles of innate lymphoid cells at the mucosal barrier: from homeostasis to pathological inflammation.Experimental & molecular medicine · 2023Review
- The enteric nervous system.Physiological reviews · 2023Review
- ILCs-Crucial Players in Enteric Infectious Diseases.International journal of molecular sciences · 2022Review
- Dengue virus co-opts innate type 2 pathways to escape early control of viral replication.Communications biology · 2022Article
- NKp46Frontiers in immunology · 2022Article
- Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses.Frontiers in immunology · 2022Article
- The potential roles of interleukin-25 in infectious diseases.Frontiers in immunology · 2022Review
- Communication is key: Innate immune cells regulate host protection to helminths.Frontiers in immunology · 2022Review
- Review
- Innate lymphoid cells and cancer: Role in tumor progression and inhibition.European journal of immunology · 2021Review
- Reparative and Maladaptive Inflammation in Tendon Healing.Frontiers in bioengineering and biotechnology · 2021Review
- Editorial: Recent Advances in the Immunology of Helminth Infection - Protection, Pathogenesis and Panaceas.Frontiers in immunology · 2021Article
- Heterogeneity in the initiation, development and function of type 2 immunity.Nature reviews. Immunology · 2020Review
- Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities.PLoS pathogens · 2020Review
- Helminth Sensing at the Intestinal Epithelial Barrier-A Taste of Things to Come.Frontiers in immunology · 2020Review
- The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group 2 innate lymphoid cells (ILC2s) were first discovered in experimental studies of intestinal helminth infection-and much of our current knowledge of ILC2 activation and function is based on the use of these models. It is perhaps not surprising therefore that these cells have also been found to play a key role in mediating protection against these large multicellular parasites. ILC2s have been intensively studied over the last decade, and are known to respond quickly and robustly to the presence of helminths-both by increasing in number and producing type 2 cytokines. These mediators function to activate and repair epithelial barriers, to recruit other innate cells such as eosinophils, and to help activate T helper 2 cells. More recent investigations have focused on the mechanisms by which the host senses helminth parasites to activate ILC2s. Such studies have identified novel stromal cell types as being involved in this process-including intestinal tuft cells and enteric neurons, which respond to the presence of helminths and activate ILC2s by producing IL-25 and Neuromedin, respectively. In the current review, we will outline the latest insights into ILC2 activation and discuss the requirement for-or redundancy of-ILC2s in providing protective immunity against intestinal helminth parasites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.