Evidence map›Paper›PMID 31019502›Full record

SynthesisFrontiers in immunology2019

2D Visualization of the Psoriasis Transcriptome Fails to Support the Existence of Dual-Secreting IL-17A/IL-22 Th17 T Cells.

Stephanie T Le, Alexander A Merleev, Guillaume Luxardi, Michiko Shimoda, Iannis E Adamopoulos, Lam C Tsoi, Jenny Z Wang, Claire Alexanian, Siba P Raychaudhuri, Samuel T Hwang and 3 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. The Immunology of Psoriasis-Current Concepts in Pathogenesis.Clinical reviews in allergy & immunology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Stephanie T LeDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Alexander A MerleevDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Guillaume LuxardiDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Michiko ShimodaDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Iannis E AdamopoulosDivision of Rheumatology, Allergy and Clinical Immunology, Department of Internal Medicine, University of California, Davis, Sacramento, CA, United States.
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, MI, United States.
Jenny Z WangDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Claire AlexanianDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Siba P RaychaudhuriDivision of Rheumatology, Allergy and Clinical Immunology, Department of Internal Medicine, University of California, Davis, Sacramento, CA, United States.
Samuel T HwangDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Johann GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, MI, United States.
Alina I MarusinaDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
Emanual MaverakisDepartment of Dermatology, University of California, Davis, Sacramento, CA, United States.
University of California, Davis · USUniversity of Michigan · USAlbert Einstein College of Medicine · USVA Northern California Health Care System · US

Funding

University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Role of IL-13 and the IL-13 Associated rs20541 Risk Variant in the Pathogenesis of PsoriasisR01AR069071 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2015 to 2019
$2.1M
NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR069071
6 · The paper itself

Abstract

The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting Th17 T cells presumably are the predominant sources of the psoriasis phenotype-driving cytokines, IL-17A and IL-22. We thus conducted a meta-analysis of independently acquired RNA-seq psoriasis datasets to explore the relationship between the expression of

Indexed as

TranscriptomeBiomarkersComputational BiologyCytokinesDisease SusceptibilityGene Expression ProfilingGene Expression RegulationHumansInflammation MediatorsInterleukin-17Interleukin-22InterleukinsMolecular ImagingPsoriasisTh17 CellsBiomarkersCytokinesIL17A protein, humanInflammation MediatorsInterleukin-17Interleukin-22InterleukinsIL17IL22machine learningneutrophilpsoriasisRNA-seqT celltranscriptome

Identifiers

PMID31019502
PMCPMC6458264
OpenAlexW2925706085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.