ArticleFrontiers in human neuroscience2019
Dysfunction of the
Article in Frontiers in human neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Altered value-based decision-making in anorexia nervosa: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Altered anticipatory brain responses in eating disorders: A neuroimaging meta-analysis.European eating disorders review : the journal of the Eating Disorders Association · 2023Pooled it
- Disgust and Self-Disgust in Eating Disorders: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Psychophysical chemosensory dysfunction in eating disorders: a qualitative systematic review.Eating and weight disorders : EWD · 2022Pooled it
- Moving towards specificity: A systematic review of cue features associated with reward and punishment in anorexia nervosa.Clinical psychology review · 2020Pooled it
- When tasty becomes threatening: a neurobehavioral perspective on subjective food preferences in eating disorders.Frontiers in psychology · 2026Review
- Global, regional, and national burden of eating disorders in 204 countries and territories, 1990-2021: findings from the Global Burden of Disease Study 2021.Journal of eating disorders · 2025Article
- Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025Review
- Differential potentiation of odor aversion and yawning by melanocortin 4 receptor signaling in distinct regions of the ventral striatum.Frontiers in neuroscience · 2025Article
- Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders.BMC medical imaging · 2024Review
- Article
- Anticipatory and consummatory pleasure in avoidant/restrictive food intake disorder.Journal of eating disorders · 2023Article
- Hypothalamic Reactivity and Connectivity following Intravenous Glucose Administration.International journal of molecular sciences · 2023Article
- Exploration of the relationships between clinical traits and functional connectivity based on surface morphology abnormalities in bulimia nervosa.Brain and behavior · 2023Article
- Exposure to a sensory functional ingredient in the pig model modulates the blood-oxygen-level dependent brain responses to food odor and acute stress during pharmacological MRI in the frontostriatal and limbic circuits.Frontiers in nutrition · 2023Article
- The potential application of event-related potentials to enhance research on reward processes in eating disorders.The International journal of eating disorders · 2022Review
- Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol.Journal of eating disorders · 2022Article
- Mesolimbic Neurobehavioral Mechanisms of Reward Motivation in Anorexia Nervosa: A Multimodal Imaging Study.Frontiers in psychiatry · 2022Article
- Adapting a neuroscience-informed intervention to alter reward mechanisms of anorexia nervosa: a novel direction for future research.Journal of eating disorders · 2021Review
- Changes in brain and behavior during food-based decision-making following treatment of anorexia nervosa.Journal of eating disorders · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain reward dysfunction in eating disorders has been widely reported. However, whether the neural correlates of hedonic and motivational experiences related to food cues are differentially affected in anorexia nervosa of restrictive type (ANr), bulimia nervosa (BN), and healthy control (HC) participants remains unknown. Here, 39 women (14 ANr, 13 BN, and 12 HC) underwent fMRI while smelling food or non-food odors in hunger and satiety states during liking and wanting tasks. ANr and BN patients reported less desire to eat odor-cued food and odor-cued high energy-density food (EDF), respectively. ANr patients exhibited lower ventral tegmental area (VTA) activation than BN patients to food odors when rating their desire to eat, suggesting altered incentive salience attribution to food odors. Compared with HC participants, BN patients exhibited decreased activation of the caudate nucleus to food odors in the hunger state during the wanting task. Both patient groups also showed reduced activation of the anterior ventral pallidum and insula in response to high EDF odors in the hunger state during the wanting task. These findings indicate that brain activation within the food reward-regulating circuit differentiates the three groups. ANr patients further exhibited lower activation of the precuneus than other participants, suggesting a possible role of body image distortion in ANr. Our study highlights that food odors are relevant sensory probes to gain better insight into the dysfunction of the mesolimbic and striatal circuitry involved in food reward processing in patients with EDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.