ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Acetaminophen Serum Concentrations in Infants Treated Intravenously for Patent Ductus Arteriosus.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Patent Ductus Arteriosus in Extremely Preterm Infants: Update on Current Diagnostic and Treatment Options.Current treatment options in cardiovascular medicine · 2025Review
- Evaluation of Serum Acetaminophen Concentration Utility for Closure of Patent Ductus Arteriosus.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Intravenous acetaminophen vs intravenous ibuprofen to close a patent ductus arteriosus closure: A pilot randomized controlled trial.Health science reports · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAlthough acetaminophen has emerged as a therapeutic option for treating hemodynamically significant patent ductus arteriosus (PDA) in preterm infants, limited data exist on pharmacodynamics. The objective of this research is to report serum acetaminophen concentrations at steady state in infants treated with intravenous acetaminophen for PDA and to examine associations with clinical outcomes.
methodsThis retrospective study evaluated all infants admitted during the study period who received intravenous acetaminophen for the treatment of PDA. Acetaminophen dosing was 15 mg/kg every 6 hours. A serum acetaminophen concentration was obtained 4 hours after the eighth dose. Associations between serum concentrations and efficacy, assessed by ductal constriction on echocardiogram, and safety, assessed by serum creatinine and hepatic transaminases, were explored using simple linear regression.
resultsA total of 36 infants were included, with a median birth weight of 720 g (IQR 585-895 g) and a median gestational age of 25 weeks (IQR 24-26 weeks). The median acetaminophen concentration in the cohort was 12.3 mg/L (IQR 6.7-16.5 mg/L; range, 1.1-29.0 mg/L). Serum acetaminophen concentrations did not correlate with infant demographics, hepatic transaminases during treatment, or duct size at treatment completion. We observed ductal closure across a wide range of serum acetaminophen concentrations.
conclusionsWe did not identify an association between acetaminophen serum concentrations following intravenous therapy and ductal response or hepatic toxicity.
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