ArticleNature2019
Structural basis of ligand recognition at the human MT
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 95 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
11.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it, 189 citations in OpenAlex.
- Research Hot Spots and Trends on Melatonin From 2000 to 2019.Frontiers in endocrinology · 2021Pooled it
- Identification of PfSR1-MT as melatonin-responsive GPCR-like candidate from the human malaria parasiteCurrent research in microbial sciences · 2026Article
- Synthesis of 1,3-Dihydro-2,1-benzisoxazoles by Intramolecular C-N Coupling: Evaluation as an Indane Bioisostere.ACS medicinal chemistry letters · 2026Article
- UHPLC-MS/MS, transcriptomic, and genomic analyses unravel the molecular mechanism on melatonin biosynthesis in Tartary buckwheat sprouts.Food chemistry. Molecular sciences · 2026Article
- Structural and Dynamics Insights into Melatonin Binding to MT1 Receptor.Chembiochem : a European journal of chemical biology · 2026Article
- Structural basis and physiological significance of non-canonical GNature communications · 2026Article
- Structure of the melatonin-related orphan receptor, GPR50.Molecules and cells · 2026Article
- ROS accelerates the progression of hypertrophic cardiomyopathy.Genes & diseases · 2026Article
- Essence of Chicken Supplementation Alters Brain and Blood Metabolite Signatures in Sleep-Deprived Mice.Metabolites · 2025Article
- Phylogenetic and Structural Insights into Melatonin Receptors in Plants: Case Study inPlants (Basel, Switzerland) · 2025Article
- Macromolecular crystallography and biology at the Linac Coherent Light Source.Journal of synchrotron radiation · 2025Article
- Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways.Nature communications · 2025Article
- A Complex Interplay Between Melatonin and RORβ: RORβ is Unlikely a Putative Receptor for Melatonin as Revealed by Biophysical Assays.Molecular neurobiology · 2025Article
- Article
- Melatonin Exerts Positive Effects on Sepsis Through Various Beneficial Mechanisms.Drug design, development and therapy · 2025Review
- Cancer Cells Show Higher Sensitivity to Melatonin-Tamoxifen Drug Conjugates than to Combination of Melatonin and Tamoxifen.ACS omega · 2024Article
- Effect of melatonin as a therapeutic strategy against intrauterine growth restriction: a mini-review of current state.Annals of medicine and surgery (2012) · 2024Review
- Multiple recent HCAR2 structures demonstrate a highly dynamic ligand binding and G protein activation mode.Nature communications · 2024Review
- G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024Article
- Structural biology in the age of X-ray free-electron lasers and exascale computing.Current opinion in structural biology · 2024Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 9 institutions in 3 countries.
Benjamin Stauch *Bridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Linda C Johansson *Bridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
John D McCorvyDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nilkanth PatelBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Gye Won HanBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Xi-Ping HuangDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cornelius GatiSLAC National Accelerator Laboratory, Bioscience Division, Menlo Park, CA, USA.
Alexander BatyukLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Samuel T SlocumDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Andrii IshchenkoBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Wolfgang BrehmCenter for Free-Electron Laser Science, DESY, Hamburg, Germany.
Thomas A WhiteCenter for Free-Electron Laser Science, DESY, Hamburg, Germany.
Nairie MichaelianBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Caleb MadsenDepartment of Physics, Arizona State University, Tempe, AZ, USA.
Lan ZhuSchool of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Thomas D GrantHauptman-Woodward Institute, Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Jessica M GrandnerBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Anna ShiriaevaBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Reid H J OlsenDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alexandra R TriboDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Saïd YousUniv Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.
Raymond C StevensBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Uwe WeierstallDepartment of Physics, Arizona State University, Tempe, AZ, USA.
Vsevolod KatritchBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Bryan L RothDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. bryan_roth@med.unc.edu.
Wei LiuSchool of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ, USA. w.liu@asu.edu.
Vadim CherezovBridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA. cherezov@usc.edu.
Convergent Science (United States) · USUniversity of North Carolina at Chapel Hill · USUniversity of Southern California · USArizona State University · USUniversität Hamburg · DECentre de Recherche Jean Pierre Aubert · FRHauptman-Woodward Medical Research Institute · USSLAC National Accelerator Laboratory · USStanford University · US
Funding
Illuminating the Druggable GPCR-omeU24DK116195 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROTH, BRYAN L., SHOICHET, BRIAN K · 2017 to 2022
$14.3MMolecular Details of Psychoactive Drug ActionsR01MH112205 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth, Brian K Shoichet · 2017 to 2026
$6.1MStructural Biology Of G Protein-Coupled ReceptorsR35GM127086 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Vadim Cherezov · 2018 to 2026
$3.6MStructure Determination of G Protein-Coupled Receptors by Microcrystal Electron DiffractionR01GM124152 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI NANNENGA, BRENT · 2017 to 2021
$1.6MStructure and Function of Dopamine ReceptorsR21DA042298 · NIDA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LIU, WEI · 2017 to 2018
$404kRegulation of Adult Hippocampal Neurogenesis by Cholecystokinin-Expressing InterneuronsF31NS093917 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLSEN, REID HANS JOHNSON · 2015 to 2017
$103kEuropean Research Council 639125NIDA NIH HHS R21 DA042298NIDDK NIH HHS U24 DK116195NIGMS NIH HHS R01 GM124152NIGMS NIH HHS R35 GM127086NIMH NIH HHS R01 MH112205NINDS NIH HHS F31 NS093917Wellcome Trust
Abstract
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms
Indexed as
ElectronsLasersModels, MolecularAcetamidesAmino Acid SequenceAntidepressive AgentsCrystallizationHumansIndenesLigandsMelatoninMolecular Docking SimulationMutationNaphthalenesReceptor, Melatonin, MT1Receptor, Serotonin, 5-HT2CAcetamidesagomelatineAntidepressive AgentsIndenesLigandsMelatoninNaphthalenesramelteonReceptor, Melatonin, MT1Receptor, Serotonin, 5-HT2C
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.