ArticleThe Journal of antibiotics2019
Molecular targets of biofabricated silver nanoparticles in Candida albicans.
Article in The Journal of antibiotics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Comprehensive insights into the role of nanocarriers in advancing azole-based ocular therapeutics.RSC advances · 2025Review
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- Possible Molecular Targeting of Biofilm-Associated Genes by Nano-Ag in Candida albicans.Applied biochemistry and biotechnology · 2024Article
- Photodynamic impact of curcumin enhanced silver functionalized graphene nanocomposites on Candida virulence.Discover nano · 2024Article
- Antifungal activity of Allyl isothiocyanate by targeting signal transduction pathway, ergosterol biosynthesis, and cell cycle inCurrent medical mycology · 2023Article
- Therapeutic Effect of Green Synthesized Silver Nanoparticles UsingMolecules (Basel, Switzerland) · 2022Article
- Silver Nanoparticles Biosynthesized with Spruce Bark Extract-A Molecular Aggregate with Antifungal Activity againstAntibiotics (Basel, Switzerland) · 2021Article
- In Vitro Antifungal Activity of Silver Nanoparticles Biosynthesized with Beech Bark Extract.Plants (Basel, Switzerland) · 2021Article
- Green Synthesis of Silver Nanoparticles Using theACS omega · 2021Article
- The use of nanoparticles as alternative therapeutic agents against Candida infections: an up-to-date overview and future perspectives.World journal of microbiology & biotechnology · 2020Review
- Effective Inhibition of Candidiasis Using an Eco-Friendly Leaf Extract ofNanomaterials (Basel, Switzerland) · 2020Article
- Silver Nanoparticles Addition in Poly(Methyl Methacrylate) Dental Matrix: Topographic and Antimycotic Studies.International journal of molecular sciences · 2019Article
- Anticandidal activity of biosynthesized silver nanoparticles: effect on growth, cell morphology, and key virulence attributes of Candida species.International journal of nanomedicine · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have analyzed the expressions of genes which regulate Ras-cAMP-EFG1 and CEK1-MAPK pathways involved in yeast to hyphal form morphogenesis in Candida albicans. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of genes involved in these pathways by the treatment with biofabricated silver nanoparticles. Cell elongation gene, ECE1, was downregulated by 5.1 fold by the treatment of silver nanoparticles. Expression of hyphal inducer gene, TEC1 was downregulated by 6.28 fold. Negative regulators of yeast to hyphal transition, TUP1 and RFG1 were downregulated by 2.45 and 5.43 fold, respectively. Current study suggests that silver nanoparticles affect gene expression and may subsequently reduce virulence in C. albicans. Targeting genes involved in virulence may be an acceptable novel treatment strategy for pathogenic fungal infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.