Evidence map›Paper›PMID 31019213›Full record

ArticleScientific reports2019

Knee osteoarthritis induces atrophy and neuromuscular junction remodeling in the quadriceps and tibialis anterior muscles of rats.

Jonathan Emanuel Cunha, Germanna Medeiros Barbosa, Paula Aiello Tomé de Souza Castro, Beatriz Leite Ferreira Luiz, Andreza Cristine Arcari Silva, Thiago Luiz Russo, Fernando Augusto Vasilceac, Thiago Mattar Cunha, Fernando Queiróz Cunha, Tania Fátima Salvini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 60 citations in OpenAlex.

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  20. [Research progress on the correlation between sarcopenia and osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jonathan Emanuel CunhaPhysical Therapy Department, Federal University of São Carlos, São Carlos, SP, Brazil.
Germanna Medeiros BarbosaPhysical Therapy Department, Federal University of São Carlos, São Carlos, SP, Brazil.
Paula Aiello Tomé de Souza CastroPhysical Therapy Department, Federal University of São Carlos, São Carlos, SP, Brazil.ORCID http://orcid.org/0000-0002-9746-6960
Beatriz Leite Ferreira LuizPhysical Therapy Department, Federal University of São Carlos, São Carlos, SP, Brazil.
Andreza Cristine Arcari SilvaPhysical Therapy Department, Federal University of São Carlos, São Carlos, SP, Brazil.
Thiago Luiz RussoPhysical Therapy Department, Federal University of São Carlos, São Carlos, SP, Brazil.ORCID http://orcid.org/0000-0002-5483-3097
Fernando Augusto VasilceacGerontology Department, Federal University of São Carlos, São Carlos, SP, Brazil.
Thiago Mattar CunhaPharmacology Department, University of São Paulo, Ribeirão Preto, SP, Brazil.
Fernando Queiróz CunhaPharmacology Department, University of São Paulo, Ribeirão Preto, SP, Brazil.
Tania Fátima SalviniPhysical Therapy Department, Federal University of São Carlos, São Carlos, SP, Brazil. tania@ufscar.br.
Universidade Federal de São Carlos · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee osteoarthritis (KOA) is associated with muscle weakness, but it is unclear which structures are involved in the muscle changes. This study assessed morphological alterations and the expression of genes and proteins linked to muscular atrophy and neuromuscular junctions (NMJs) in KOA, induced by anterior cruciate ligament transection (ACLT) in rats. Two groups of rats were assessed: control (without intervention) and KOA (ACLT surgery in the right knee). After 8 weeks, quadriceps, tibialis anterior (TA) and gastrocnemius muscles were analyzed (area of muscle fibers, NMJ, gene and protein expression). KOA group showed atrophy in quadriceps (15.7%) and TA (33%), with an increase in atrogin-1 and muscle RING-finger protein-1 (MuRF-1). KOA group showed quadriceps NMJ remodeling (reduction area and perimeter) and decrease in NMJ diameter in TA muscle. The expression of nicotinic acetylcholine receptor (nAChR) γ-nAChR increased and that of α-nAChR and muscle specific tyrosine kinase (MuSK) declined in the quadriceps, with a decrease in ε-nAChR in TA. MuRF-1 protein expression increased in quadriceps and TA, with no changes in neural cell adhesion molecule (NCAM). In conclusion, ACLT-induced KOA promotes NMJ remodeling and atrophy in quadriceps and TA muscles, associated with inflammatory signs and changes in muscle gene and protein expression.

Indexed as

AnimalsAnterior Cruciate LigamentGene ExpressionMuscle ProteinsMuscle, SkeletalMuscle WeaknessMuscular AtrophyNeuromuscular JunctionOsteoarthritis, KneeQuadriceps MuscleRats, WistarReceptor Protein-Tyrosine KinasesReceptors, NicotinicSKP Cullin F-Box Protein LigasesTripartite Motif ProteinsUbiquitin-Protein LigasesFbxo32 protein, ratMuscle ProteinsReceptor Protein-Tyrosine KinasesReceptors, NicotinicSKP Cullin F-Box Protein LigasesTrim63 protein, ratTripartite Motif ProteinsUbiquitin-Protein Ligases

Identifiers

PMID31019213
PMCPMC6482306
OpenAlexW2941452365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.