ArticleNeurology2019
Blood pressure and dementia: What the SPRINT-MIND trial adds and what we still need to know.
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Frontiers and hotspot evolution in research on Alzheimer's disease and hypertension: a bibliometric analysis from 2004 to 2023.Frontiers in neurology · 2025Pooled it
- Evaluation of Intensive vs Standard Blood Pressure Reduction and Association With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of cognitive impairment and dementia.The Cochrane database of systematic reviews · 2021Pooled it
- Pooled it
- Trial
- Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial.AJNR. American journal of neuroradiology · 2023Trial
- Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Trial
- Effect of intensive blood pressure control on subtypes of mild cognitive impairment and risk of progression from SPRINT study.Journal of the American Geriatrics Society · 2022Trial
- Analysis of the Genetic Comorbid Mechanisms of Type 2 Diabetes, Alzheimer's Disease, and Hypertension Using Network Modularization.BioMed research international · 2026Article
- Obesity, Hypertension and Brain Health.Current hypertension reports · 2025Review
- Chinese Guidelines for the Prevention and Treatment of Hypertension (2024 revision).Journal of geriatric cardiology : JGC · 2025Article
- Cumulative blood pressure load and cognitive decline in older adults: An observational analysis of two large cohorts.Cerebral circulation - cognition and behavior · 2025Article
- Vascular cognitive impairment and dementia: Mechanisms, treatment, and future directions.International journal of stroke : official journal of the International Stroke Society · 2024Review
- Review
- The Relation Between Arterial Hypertension and Cognitive Impairment: A Literature Review.Cureus · 2024Review
- What have clinical trials taught us about brain health?Cerebral circulation - cognition and behavior · 2024Article
- Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Observational
- Hypertension and Stroke as Mediators of Air Pollution Exposure and Incident Dementia.JAMA network open · 2023Article
- Population attributable fraction of hypertension for dementia: global, regional, and national estimates for 186 countries.EClinicalMedicine · 2023Article
- Testing times for dementia: a community survey identifying contemporary barriers to risk reduction and screening.Alzheimer's research & therapy · 2023Article
Corrections and comments
- Comment on
Authors and funding
4 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
31019101What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.