Evidence map›Paper›PMID 31019095›Full record

ArticleRNA (New York, N.Y.)2019

2'-

Isabel Freund, Daniel K Buhl, Sébastien Boutin, Annika Kotter, Florian Pichot, Virginie Marchand, Tim Vierbuchen, Holger Heine, Yuri Motorin, Mark Helm and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  11. Article
  12. Article
  13. RNA modifications in cancer.British journal of cancer · 2023
    Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Isabel FreundDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Daniel K BuhlDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Sébastien BoutinDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Annika KotterInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
Florian PichotInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
Virginie MarchandUMS2008 IBSLor, CNRS-Lorraine University-INSERM, BioPole Lorraine University, 54500 Vandoeuvre-les-Nancy, France.
Tim VierbuchenDivision of Innate Immunity, Research Center Borstel, 23845 Borstel, Germany.ORCID 0000-0003-3110-4155
Holger HeineDivision of Innate Immunity, Research Center Borstel, 23845 Borstel, Germany.ORCID 0000-0001-8128-5068
Yuri MotorinIMoPA UMR7365 CNRS-Lorraine University, BioPole Lorraine University, 54500 Vandoeuvre-les-Nancy, France.
Mark HelmInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
Alexander H DalpkeDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Tatjana EigenbrodDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-7247-9290
Heidelberg University · DECentre National de la Recherche Scientifique · FRJohannes Gutenberg University Mainz · DEResearch Center Borstel - Leibniz Lung Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial RNA has emerged as an important activator of innate immune responses by stimulating Toll-like receptors TLR7 and TLR8 in humans. Guanosine 2'-

Indexed as

EndosomesEukaryotic CellsGuanosineHumansImmunity, InnateMethylationProkaryotic CellsRNA, TransferToll-Like ReceptorstRNA MethyltransferasesGuanosineRNA, TransferToll-Like ReceptorstRNA Methyltransferases2′-O-methylationbacterial RNAimmune stimulationRNA modificationTLR

Identifiers

PMID31019095
PMCPMC6573781
OpenAlexW2940931641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.