Evidence map›Paper›PMID 31019084›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in

Christopher M Uyehara, Daniel J McKay

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
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  6. High-Efficiency Genomic Mapping of Chromatin-Associated Targets with CUT&RUN.Methods in molecular biology (Clifton, N.J.) · 2026
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  10. bioRxiv : the preprint server for biology · 2025
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  15. A hormone-to-neuropeptide pathway inhibits sexual receptivity in immatureProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher M UyeharaDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0002-3210-9428
Daniel J McKayDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; dmckay1@email.unc.edu.ORCID 0000-0001-8226-0604
University of North Carolina at Chapel Hill · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
NIGMS NIH HHS R35 GM128851NIGMS NIH HHS T32 GM007092NIH HHS P40 OD018537
6 · The paper itself

Abstract

The ecdysone pathway was among the first experimental systems employed to study the impact of steroid hormones on the genome. In

Indexed as

Metamorphosis, BiologicalAnimalsDNA-Binding ProteinsDrosophilaDrosophila ProteinsEcdysoneGene Expression Regulation, DevelopmentalGenome, InsectReceptors, SteroidTranscription FactorsWings, AnimalDNA-Binding ProteinsDrosophila ProteinsEcdysoneecdysone receptorReceptors, SteroidTranscription FactorsUSP protein, DrosophilaCUT&RUNecdysonehormonetemporal gene regulationtranscription factor

Identifiers

PMID31019084
PMCPMC6525475
OpenAlexW2909542449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.