Evidence map›Paper›PMID 31019048›Full record

ArticleJournal of virology2019

Type I Interferon Receptor Signaling Drives Selective Permissiveness of Astrocytes and Microglia to Measles Virus during Brain Infection.

Jeremy Charles Welsch, Benjamin Charvet, Sebastien Dussurgey, Omran Allatif, Noemie Aurine, Branka Horvat, Denis Gerlier, Cyrille Mathieu

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Abortive and productive infection of CNS cell types following in vivo delivery of VSV.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jeremy Charles WelschCIRI, International Center for Infectiology Research, CIRI, International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France jrmy.welsch@gmail.com cyrille.mathieu@inserm.fr.
Benjamin CharvetCIRI, International Center for Infectiology Research, CIRI, International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France.
Sebastien DussurgeySFR BioSciences, INSERM, CNRS, UMS3444/US8, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Omran AllatifCIRI, International Center for Infectiology Research, CIRI, International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France.
Noemie AurineCIRI, International Center for Infectiology Research, CIRI, International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France.
Branka HorvatCIRI, International Center for Infectiology Research, CIRI, International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France.ORCID 0000-0003-0578-7765
Denis GerlierCIRI, International Center for Infectiology Research, CIRI, International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France.ORCID 0000-0001-5539-456X
Cyrille MathieuCIRI, International Center for Infectiology Research, CIRI, International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France jrmy.welsch@gmail.com cyrille.mathieu@inserm.fr.
Université Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatal neurological syndromes can occur after measles virus (MeV) infection of the brain. The mechanisms controlling MeV spread within the central nervous system (CNS) remain poorly understood. We analyzed the role of type I interferon (IFN-I) receptor (IFNAR) signaling in the control of MeV infection in a murine model of brain infection. Using organotypic brain cultures (OBC) from wild-type and IFNAR-knockout (IFNAR

Indexed as

AnimalsAntiviral AgentsAstrocytesBrainCentral Nervous SystemCytokinesFemaleHippocampusHumansMaleMeaslesMeasles virusMiceMice, KnockoutMicrogliaNeuronsAntiviral AgentsCytokinesIFNAR1 protein, humanReceptor, Interferon alpha-betaSignaling Lymphocytic Activation Molecule Family Member 1SLAMF1 protein, humanastrogliosiscell permissivenesscentral nervous system infectionsinterferonsmeasles virusorganotypic brain cultures

Identifiers

PMID31019048
PMCPMC6580971
OpenAlexW2940591986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.