Evidence map›Paper›PMID 31019022›Full record

ArticleThe oncologist2019

Degree of

Kate Lynn J Bill, Nathan D Seligson, John L Hays, Achal Awasthi, Bryce Demoret, Colin W Stets, Megan C Duggan, Manojkumar Bupathi, Guy N Brock, Sherri Z Millis and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in The oncologist, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. [One case of hypopharyngeal dedifferentiated liposarcoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  10. Circulating Biomarkers in Sarcoma.Current oncology reports · 2025
    Review
  11. Article
  12. Article
  13. Oncogenic Functions of Alternatively SplicedInternational journal of molecular sciences · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Advancements in MDM2 inhibition: Clinical and pre-clinical investigations of combination therapeutic regimens.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Review
  18. Treatment of De-Differentiated Liposarcoma in the Era of Immunotherapy.International journal of molecular sciences · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Kate Lynn J BillDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
Nathan D SeligsonWexner Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
John L HaysDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Achal AwasthiDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Bryce DemoretDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
Colin W StetsDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
Megan C DugganWexner Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Manojkumar BupathiDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Guy N BrockDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
Sherri Z MillisFoundation Medicine Inc., Cambridge, Massachusetts, USA.
Reena ShakyaWexner Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Cynthia D TimmersWexner Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Paul E WakelyDepartment of Pathology, The Ohio State University, Columbus, Ohio, USA.
Raphael E PollockDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
James L ChenDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA James.Chen@osumc.edu.
The Ohio State University · USThe Ohio State University Wexner Medical Center · USFoundation Medicine (United States)

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Translational Training Grant in Experimental TherapeuticsK12CA133250 · NCI · OHIO STATE UNIVERSITY · PI WILLIAM E. CARSON, Rosa Lapalombella · 2008 to 2026
$15.0M
Decoding tumors to achieve better clinical outcomesR50CA211529 · NCI · OHIO STATE UNIVERSITY · PI TIMMERS, CYNTHIA · 2017 to 2019
$515k
NCI NIH HHS K12 CA133250NCI NIH HHS P30 CA016058NCI NIH HHS R50 CA211529
6 · The paper itself

Abstract

backgroundDedifferentiated liposarcomas (DDLPS) are mesenchymal tumors associated with universally poor response to treatment. Genomic amplification of murine double minute 2 ( PATIENTS AND

methodsThe distribution of

resultsGenomic

conclusionIMPLICATIONS FOR PRACTICE: No validated biomarkers exist for treatment selection in dedifferentiated liposarcoma (DDLPS). Although murine double minute 2 (

Indexed as

Gene AmplificationAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisCell ProliferationCombined Modality TherapyDeoxycytidineDocetaxelDrug Resistance, NeoplasmFemaleFollow-Up StudiesGemcitabineHumansLiposarcomaMiceNeoplasm Recurrence, LocalDeoxycytidineDocetaxelGemcitabineMDM2 protein, humanProto-Oncogene Proteins c-mdm2BiomarkerDedifferentiated liposarcomasDoxorubicinMDM2p53

Identifiers

PMID31019022
PMCPMC6656442
OpenAlexW2941042007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.