ArticleBMC pediatrics2019
Feasibility study and reference values of FibroScan 502 with M probe in healthy preschool children aged 5 years.
Article in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 27 citations in OpenAlex.
- Ferritin and Liver Steatosis in Children: Interactions Between Metabolic Clustering andInternational journal of molecular sciences · 2026Article
- Vibration-controlled transient elastography in pediatric metabolic dysfunction-associated steatotic liver disease.Journal of pediatric gastroenterology and nutrition · 2026Article
- Cystic fibrosis hepatobiliary involvement: an update on imaging in diagnosis and monitoring.Pediatric radiology · 2024Review
- Prevalence and incidence of MAFLD and associated anthropometric parameters among prepubertal children of the Shanghai Birth Cohort.Hepatology international · 2023Article
- Nonalcoholic fatty liver disease and insulin resistance in children.Clinical and experimental pediatrics · 2023Article
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- Liver transient elastography values in healthy South African children.BMC pediatrics · 2023Article
- Exploring the Potential Performance of Fibroscan for Predicting and Evaluating Metabolic Syndrome using a Feature Selected Strategy of Machine Learning.Metabolites · 2023Article
- Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children.Epigenetics · 2022Article
- Correlation between Transient Elastography (FibroscanPediatric gastroenterology, hepatology & nutrition · 2022Article
- Association of maternal obesity and gestational diabetes mellitus with overweight/obesity and fatty liver risk in offspring.World journal of gastroenterology · 2022Article
- Defining values for controlled attenuation parameter and liver stiffness in youth without liver disease.Pediatric research · 2022Article
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- Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage.Frontiers in endocrinology · 2022Article
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- Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease.Hepatology communications · 2020Article
- Correlation between Serum Ferritin Levels and Liver Stiffness measured by Fibroscan in patients with Chronic Hepatitis C.Pakistan journal of medical sciencesArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient elastography (TE) using FibroScan with M probe has been widely used in adults for controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). In this study, we aimed to assess the feasibility of this approach and reference values of CAP and LSM in healthy preschool children aged 5 years.
methodsFibroScan-502 with M probe (Echosens, Paris, France) and bioelectrical impedance analysis (InBody 720, Biospace, South Korea) were prospectively conducted in healthy children aged 5 years from the Shanghai Prenatal Cohort Study. Linear regression models and piece-wise linear regression models were used to explore the factors associated with CAP and LSM.
resultsThe success rate of a valid TE measurement was 96.5% in 452 healthy preschool children aged 5 years, and 436 children with 236 boys were included for further study. The median, inter quartile range (IQR) and the 5th-95th percentiles of CAP values were 171.50, 162.07-188.13 and 154.21-214.53 dB/m, respectively. The median, mean ± standard deviation and the 5th-95th percentiles of LSM were 3.20, 3.28 ± 0.86 and 2.00-4.78 kPa, respectively. In multivariate linear regression analyses, the CAP but not the LSM value was significantly positively correlated with such anthropometric index as body weight, body mass index, waist circumference, body fat content and body fat percentage.
conclusionsFibroScan-502 with M-probe can be used to measure CAP and LSM in preschool children aged 5 years. The 95th percentiles of CAP values and LSM were 214.53 dB/m and 4.78 kPa, respectively. Further study should be performed to explore the cut-off values of CAP and LSM for diagnosis of hepatic steatosis and fibrosis in children.
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