Evidence map›Paper›PMID 31018833›Full record

ReviewBMC pediatrics2019

The various clinical spectra of juvenile xanthogranuloma: imaging for two case reports and review of the literature.

Michaela Höck, Bernhard Zelger, Gisela Schweigmann, Barbara Brunner, Bettina Zelger, Gabriele Kropshofer, Ursula Kiechl-Kohlendorfer

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. [Benign skin neoplasms in children].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michaela HöckDepartment of Paediatrics II Neonatology, Medical University of Innsbruck, 6020, Innsbruck, Austria. Michaela.hoeck@i-med.ac.at.ORCID 0000-0001-7855-0617
Bernhard ZelgerDepartment of Dermatology and Venerology, Medical University of Innsbruck, Innsbruck, Austria.
Gisela SchweigmannDepartment of Radiology, Medical University of Innsbruck, Innsbruck, Austria.
Barbara BrunnerDepartment of Paediatrics II Neonatology, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Bettina ZelgerDepartment of Pathology, Medical University of Innsbruck, Innsbruck, Austria.
Gabriele KropshoferDepartment of Paediatrics I Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Ursula Kiechl-KohlendorferDepartment of Paediatrics II Neonatology, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Innsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJuvenile xanthogranuloma (JXG) belongs to the heterogeneous group of non-Langerhans cell histiocytosis and is caused by an accumulation and proliferation of macrophages. In the majority of cases JXG is a disorder of early childhood presenting during the first 2 years of life. The typical presentation is a solitary reddish or yellowish skin papule or nodule with spontaneous regression and no need for treatment. CASE PRESENTATION: Two infants with an atypical presentation of JXG, one with multiple blueberry muffin rash-like skin lesions and the other with severe multi-systemic involvement, are reported. Diagnosis was established by skin biopsy including histological work-up and immunostaining, where markers for macrophages (CD68 and CD163) exhibited significant reactivity.

conclusionJXG is the most common of the non-Langerhans cell histiocytosis. The typical presentation is a solitary skin lesion. The purpose of this report is to familiarize paediatricians with an unusual variant of this entity in order to facilitate early diagnosis and raise awareness for possible visceral complications and associated medical conditions.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBiopsy, NeedleFemaleFollow-Up StudiesHumansImmunohistochemistryInfantMagnetic Resonance ImagingMaleRisk AssessmentTime FactorsTreatment OutcomeWatchful WaitingXanthogranuloma, JuvenileBlueberry muffin babyCase reportHistopathologyJuvenile xanthogranulomaNon-Langerhans cell histiocytosisSystemic

Identifiers

PMID31018833
PMCPMC6482499
OpenAlexW2947293680

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.