Evidence map›Paper›PMID 31018749›Full record

ArticleJournal of the American Heart Association2019

Abnormal DNA Methylation Induced by Hyperglycemia Reduces CXCR 4 Gene Expression in CD 34

Vera Vigorelli, Jessica Resta, Valentina Bianchessi, Andrea Lauri, Beatrice Bassetti, Marco Agrifoglio, Maurizio Pesce, Gianluca Polvani, Giorgia Bonalumi, Laura Cavallotti and 4 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Epigenetic regulation in a high-sugar environment (Review).International journal of molecular medicine · 2026
    Review
  4. Review
  5. Observational
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Smoking and Diabetes Attenuate Number of CD34International journal of molecular sciences · 2023
    Article
  15. Article
  16. Liraglutide preserves CD34Cardiovascular diabetology · 2022
    Article
  17. Review
  18. Type 1 diabetes patients increase CXCR4Scientific reports · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vera Vigorelli1 IRCCS Centro Cardiologico Monzino Milan Italy.
Jessica Resta1 IRCCS Centro Cardiologico Monzino Milan Italy.
Valentina Bianchessi1 IRCCS Centro Cardiologico Monzino Milan Italy.
Andrea Lauri2 Molecular Biology Unit Axxam SpA Milan Italy.
Beatrice Bassetti1 IRCCS Centro Cardiologico Monzino Milan Italy.
Marco Agrifoglio1 IRCCS Centro Cardiologico Monzino Milan Italy.
Maurizio Pesce1 IRCCS Centro Cardiologico Monzino Milan Italy.
Gianluca Polvani1 IRCCS Centro Cardiologico Monzino Milan Italy.
Giorgia Bonalumi1 IRCCS Centro Cardiologico Monzino Milan Italy.
Laura Cavallotti1 IRCCS Centro Cardiologico Monzino Milan Italy.
Francesco Alamanni1 IRCCS Centro Cardiologico Monzino Milan Italy.
Stefano Genovese1 IRCCS Centro Cardiologico Monzino Milan Italy.
Giulio Pompilio1 IRCCS Centro Cardiologico Monzino Milan Italy.
Maria Cristina Vinci1 IRCCS Centro Cardiologico Monzino Milan Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background CD 34

Indexed as

DNA MethylationAgedAntigens, CD34Bone Marrow CellsCatalaseChemokine CXCL12Chromatin ImmunoprecipitationCoronary Artery BypassCoronary Artery DiseaseDiabetes MellitusDown-RegulationEpigenesis, GeneticGene Expression RegulationHumansHyperglycemiaIn Vitro TechniquesAntigens, CD34CatalaseChemokine CXCL12CXCR4 protein, humanReactive Oxygen SpeciesReceptors, CXCR4RNA, MessengerRNA Polymerase IISHC1 protein, humanSrc Homology 2 Domain-Containing, Transforming Protein 1Superoxide Dismutasecardiovascular complicationsCD34 stem cellsCXCR4diabetes mellitusDNA methylationhistone modificationsmetabolic memory

Identifiers

PMID31018749
PMCPMC6512087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.