ArticleJournal of applied physiology (Bethesda, Md. : 1985)2019
Preterm birth disrupts the development of feeding and breathing coordination.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants.The Cochrane database of systematic reviews · 2021Pooled it
- Article
- A ducted, biomimetic nipple replicates breastfeeding mechanics through ontogeny in an infant animal model.Pediatric research · 2026Article
- Regional Heterogeneity in the Electromyography Activity of Extrinsic Tongue Muscles Is Critical to Tongue Function.Integrative and comparative biology · 2025Article
- Evaluating the Impact of Nipple Design on Tongue Function in Infant Feeding Using a Dynamic Endocast.Integrative and comparative biology · 2025Article
- Infant pigs demonstrate motor adaptation across multiple physiologic functions during feeding in response to dynamic changes in milk flow rate.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- A Ducted, Biomimetic Nipple Improves Aspects of Infant Feeding Physiology and Performance in an Animal Model.Dysphagia · 2025Article
- Muscle function and electromyography: (almost) 70 years since Doty and Bosma (1956).Journal of neurophysiology · 2025Article
- Longitudinal Changes in Aerodigestive Responses to Varying Nipple Properties in Infant Pigs.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- An alternate to accumulated oxygen deficit (AOD) for measuring anaerobic contribution: 'AOD_alt' is valid in normoxia and hypoxia.European journal of applied physiology · 2025Article
- The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- The Impact of Varying Nipple Properties on Infant Feeding Physiology and Performance Throughout Ontogeny in a Validated Animal Model.Dysphagia · 2024Article
- Biomechanical and Cortical Control of Tongue Movements During Chewing and Swallowing.Dysphagia · 2024Review
- Impact of volume and rate of milk delivery on coordination of respiration and swallowing in infant pigs.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- The Function of the Mammal Extrinsic Tongue Musculature in the Transition from Suckling to Drinking.Integrative and comparative biology · 2023Article
- Developmental factors influencing bone strength in precocial mammals: An infant pig model.Journal of anatomy · 2023Article
- Preterm pigs for preterm birth research: reasonably feasible.Frontiers in physiology · 2023Review
- Oropharyngeal capsaicin exposure improves infant feeding performance in an animal model of superior laryngeal nerve damage.Journal of neurophysiology · 2022Article
- The role of skin-to-skin contact in exclusive breastfeeding: a cohort study.Revista de saude publica · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
All mammals must breathe and breathe continuously from birth. Similarly, all mammals, including infants, have high functional demands for feeding. However, the pathway that food takes through the pharynx interrupts respiration. The coordination between swallowing and breathing is therefore critical for all infant mammals. Clinically, this coordination differs between term and preterm infants. However, the neurological mechanisms underlying this coordination and how it matures as infants grow are poorly understood. Here, we integrate high-resolution data from multiple physiologic processes across a longitudinal time frame to study suck-swallow-breathe dynamics in a preterm animal model, the infant pig. In doing so, we test the hypothesis that preterm birth will have an impact on some, but not all, behaviors associated with suck-swallow-breath performance. We hypothesize that coordination will be disrupted, reflecting incomplete connections in the brainstem. We found that preterm pigs became rhythmic and mature in sucking and swallowing behaviors, suggesting substantial postnatal maturation in the coordination of these behaviors. However, their ability to coordinate swallowing and breathing never developed. These results have implications for the nature of clinical care of human infants, as well as for how feeding processes develop in mammals. Clinically, they provide a foundation for developing interventions for preterm infants. Additionally, these results suggest that the lack of coordination between swallowing and breathing may be a significant factor in determining the minimum gestation time across mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.