Evidence map›Paper›PMID 31018734›Full record

ArticleJournal of biological rhythms2019

Pregnancy Induces an Earlier Chronotype in Both Mice and Women.

Carmel A Martin-Fairey, Peinan Zhao, Leping Wan, Till Roenneberg, Justin Fay, Xiaofeng Ma, Ronald McCarthy, Emily S Jungheim, Sarah K England, Erik D Herzog

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological rhythms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Carmel A Martin-FaireyDepartment of Biology, Washington University, St. Louis, MO, USA.
Peinan ZhaoDepartment of Obstetrics and Gynecology, Washington University, St. Louis, MO, USA.
Leping WanDepartment of Obstetrics and Gynecology, Washington University, St. Louis, MO, USA.
Till RoennebergInstitute for Medical Psychology, Department of Human Chronobiology, Ludwig-Maximilians-University, Munich, Germany.
Justin FayDepartment of Biology, University of Rochester, Rochester, NY, USA.
Xiaofeng MaDepartment of Obstetrics and Gynecology, Washington University, St. Louis, MO, USA.
Ronald McCarthyDepartment of Obstetrics and Gynecology, Washington University, St. Louis, MO, USA.
Emily S JungheimDepartment of Obstetrics and Gynecology, Washington University, St. Louis, MO, USA.
Sarah K EnglandDepartment of Obstetrics and Gynecology, Washington University, St. Louis, MO, USA.
Erik D HerzogDepartment of Biology, Washington University, St. Louis, MO, USA.
Washington University in St. Louis · USLudwig-Maximilians-Universität München · DEUniversity of Rochester · US

Funding

Training in Reproductive SciencesT32HD049305 · NICHD · WASHINGTON UNIVERSITY · PI MOLEY, KELLE H · 2005 to 2015
$1.9M
ROLE OF PERIPHERAL OSCILLATORS IN THE TIMING OF BIRTHF32HD093269 · NICHD · WASHINGTON UNIVERSITY · PI MARTIN-FAIREY, CARMEL · 2017 to 2018
$122k
NICHD NIH HHS F32 HD093269NICHD NIH HHS T32 HD049305
6 · The paper itself

Abstract

Daily rhythms generated by endogenous circadian mechanisms and synchronized to the light-dark cycle have been implicated in the timing of birth in a wide variety of species. Although chronodisruption (e.g., shift work or clock gene mutations) is associated with poor reproductive outcomes, little is known about circadian timing during pregnancy. This study tested whether daily rhythms change during full-term pregnancies in mice and women. We compared running wheel activity continuously in both nonpregnant ( n = 14) and pregnant ( n = 13) 12- to 24-week-old C57BL/6NJ mice. We also monitored wrist actigraphy in women ( N = 39) for 2 weeks before conception and then throughout pregnancy and measured daily times of sleep onset. We found that on the third day of pregnancy, mice shift their activity to an earlier time compared with nonpregnant dams. Their time of daily activity onset was maximally advanced by almost 4 h around day 7 of pregnancy and then shifted back to the nonpregnant state approximately 1 week before delivery. Mice also showed reduced levels of locomotor activity during their last week of pregnancy. Similarly, in women, the timing of sleep onset was earlier during the first and second trimesters (gestational weeks 4-13 and 14-27) than before pregnancy and returned to the prepregnant state during the third trimester (weeks 28 until delivery). Women also showed reduced levels of locomotor activity throughout pregnancy. These results indicate that pregnancy induces changes in daily rhythms, altering both time of onset and amount of activity. These changes are conserved between mice and women.

Indexed as

Circadian RhythmLocomotionPhotoperiodPregnancySleepActigraphyAdultAnimalsFemaleHumansMiceMice, Inbred C57BLPhenotypeTime Factorschronodisruptionchronotypecircadian rhythmdeliverylocomotor activitypregnancy

Identifiers

PMID31018734
PMCPMC7408307
OpenAlexW2941007691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.