Evidence map›Paper›PMID 31018542›Full record

ArticleInternational journal of molecular sciences2019

Liver Sinusoidal Endothelial Cells Promote the Expansion of Human Cord Blood Hematopoietic Stem and Progenitor Cells.

Huilin Li, Haiyun Pei, Xiaoyan Xie, Sihan Wang, Yali Jia, Bowen Zhang, Zeng Fan, Yiming Liu, Yun Bai, Yi Han and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Fetal liver CD34Stem cell research & therapy · 2024
    Article
  3. Article
  4. Review
  5. Ex Vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells.Advances in experimental medicine and biology · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Huilin LiStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. ice199303@163.com.
Haiyun PeiExperimental Hematology and Biochemistry Lab, Beijing Institute of Radiation Medicine, Beijing 100850, China. peihy@hotmail.com.
Xiaoyan XieStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. alpha13@126.com.
Sihan WangStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. wangsihan_lk@hotmail.com.
Yali JiaExperimental Hematology and Biochemistry Lab, Beijing Institute of Radiation Medicine, Beijing 100850, China. yaly_bio@163.com.
Bowen ZhangExperimental Hematology and Biochemistry Lab, Beijing Institute of Radiation Medicine, Beijing 100850, China. fish_zbw1985@163.com.
Zeng FanStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. fan17930@yeah.net.
Yiming LiuStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. liuym07@126.com.
Yun BaiStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. josephinebyzy@163.com.
Yi HanSouth China Research Center for Stem Cell & Regenerative Medicine, SCIB, Guangzhou 510005, China. yemuhan@163.com.
Lijuan HeStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. hlj821@163.com.
Xue NanStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. diamond_girl263@126.com.
Wen YueStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. wenyue226@126.com.
Xuetao PeiStem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China. peixt@nic.bmi.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cord blood (CB) is an attractive source of hematopoietic stem cells (HSCs) for hematopoietic cell transplantation. However, its application remains limited due to the low number of HSCs/progenitors in a single CB unit and its notoriously difficulty in expanding ex vivo. Here, we demonstrated that the human fetal liver sinusoidal endothelial cells engineered to constitutively express the adenoviral

Indexed as

AnimalsAntigens, CD34Cell DifferentiationCell ProliferationCells, CulturedCoculture TechniquesEndothelial CellsHematopoiesisHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansLiverMiceAntigens, CD34expansionhematopoietic stem and progenitor cellsliver sinusoidal endothelial cellsmicroenvironmenttransplantation

Identifiers

PMID31018542
PMCPMC6515002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.